CAS 10246-75-0

hydroxyzine pamoate

Description:

Hydroxyzine pamoate is a medication primarily used for its antihistaminic and anxiolytic properties. It is a salt form of hydroxyzine, which is an antihistamine that can alleviate symptoms of allergies, anxiety, and nausea. The pamoate salt enhances its solubility and bioavailability. Hydroxyzine pamoate is typically administered orally and is known for its sedative effects, making it useful in treating anxiety disorders and as a premedication for surgical procedures. The compound exhibits a relatively high molecular weight and is characterized by its ability to cross the blood-brain barrier, contributing to its central nervous system effects. It is important to note that hydroxyzine pamoate may cause side effects such as drowsiness, dry mouth, and dizziness. As with any medication, it should be used under the guidance of a healthcare professional, considering potential interactions with other drugs and individual patient factors.

Formula: C₂₃H₁₆O₆·C₂₁H₂₇ClN₂O₂

InChI: InChI=1S/C23H16O6.C21H27ClN2O2/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-10,24-25H,11H2,(H,26,27)(H,28,29);1-9,21,25H,10-17H2

InChI key: InChIKey=ASDOKGIIKXGMNB-UHFFFAOYSA-N

SMILES: C(C=1C2=C(C=C(C(O)=O)C1O)C=CC=C2)C=3C4=C(C=C(C(O)=O)C3O)C=CC=C4.C(N1CCN(CCOCCO)CC1)(C2=CC=C(Cl)C=C2)C3=CC=CC=C3

Synonyms:

• 1-(p-Chloro-α-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine, pamoate
• 2-(2-(4-((4-Chlorophenyl)(Phenyl)Methyl)Piperazin-1-Yl)Ethoxy)Ethanol 4,4′-Methylenebis(3-Hydroxy-2-Naphthoate)
• 2-(2-{4-[(4-Chlorophenyl)(Phenyl)Methyl]Piperazin-1-Yl}Ethoxy)Ethanol
• 2-Naphthalenecarboxylic acid, 4,4′-methylenebis[3-hydroxy-, compd. with 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol (1:1)
• 2-Naphthoic acid, 4,4′-methylenebis[3-hydroxy-, compd. with 2-[2-[4-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol (1:1)
• 2-Naphthoic acid, 4,4′-methylenebis[3-hydroxy-, hydroxyzine salt
• 4,4'-Methanediylbis(3-Hydroxynaphthalene-2-Carboxylic Acid) - 2-(2-{4-[(4-Chlorophenyl)(Phenyl)Methyl]Piperazin-1-Yl}Ethoxy)Ethanol (1:1)
• Atarax P
• Equipose
• Ethanol, 2-[2-[4-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]-, 4,4′-methylenebis[3-hydroxy-2-naphthoate] (1:1) (salt)
• Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, 4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (1:1)
• Hydroxyzine Embonate
• Hydroxyzyne pamoate
• Masmoran
• Paxisitil
• Paxistil
• Vistaril

Hydroxyzine Pamoate

CAS: 10246-75-0

Color and Shape: Neat

Ref: 61-FOR3107.00

Hydroxyzine Pamoate

CAS: 10246-75-0

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₂₁H₂₇ClN₂O₂·C₂₃H₁₆O₆

Color and Shape: Light Yellow Powder

Molecular weight: 763.27

Ref: 45-1334006

Hydroxyzine pamoate

CAS: 10246-75-0

Formula: C₄₄H₄₃ClN₂O₈

Purity: 96%

Color and Shape: Solid

Molecular weight: 763.2738

Ref: IN-DA007FBV

Hydroxyzine Pamoate

CAS: 10246-75-0

Hydroxyzine Pamoate (Bobsule) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria and histamine-mediated pruritus.

Formula: C₄₄H₄₃ClN₂O₈

Purity: 99.49%

Color and Shape: Solid

Molecular weight: 763.27

Ref: TM-T0053

Hydroxyzine Pamoate

CAS: 10246-75-0

Hydroxyzine Pamoate

Purity: ≥98%

Molecular weight: 763.27g/mol

Ref: 54-BUP15032

Hydroxyzine Pamoate

Controlled Product

CAS: 10246-75-0

Formula: C₂₃H₁₆O₆·C₂₁H₂₇ClN₂O₂

Color and Shape: Neat

Molecular weight: 763.27

Ref: 86-MM3107.00

Hydroxyzine pamoate

Controlled Product

CAS: 10246-75-0

Hydroxyzine pamoate is a drug that belongs to the group of H1 antagonists. It is used for the treatment of allergic reactions, bowel disease, and infectious diseases. Hydroxyzine pamoate has been shown to have a low potency in animals and humans, with a high incidence of side effects. This drug may act by competing with histamine at the receptor sites on mast cells or basophils. The matrix effect of this drug is unclear. Hydroxyzine pamoate has been shown to inhibit protein synthesis in some bacteria and can be used as an analytical method for detecting histamine in human blood samples.

Formula: C₄₄H₄₃ClN₂O₈

Purity: Min. 95%

Color and Shape: White To Light (Or Pale) Yellow Solid

Molecular weight: 763.27 g/mol

Ref: 3D-FH171674

Hydroxyzine Pamoate

CAS: 10246-75-0

Applications Hydroxyzine Pamoate is an H1 receptor antagonist. Anxiolytic. Antihistaminic.
References De Bruyn, T. et al.: Mol. Pharm., 83, 1257 (2013); Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Tsau, J., et al.: Anal. Profiles Drug Subs., 7, 319 (1978)

Formula: C₂₃H₁₆O₆·C₂₁H₂₇ClN₂O₂

Color and Shape: Neat

Molecular weight: 763.27

Ref: TR-H996505

Hydroxyzine Pamoate

CAS: 10246-75-0

Formula: C₂₁H₂₇ClN₂O₂C₂₃H₁₆O₆

Molecular weight: 374.9 : 388.4

Ref: ST-EA-CP-H11010