CAS 1025097-10-2

Cadazolid

Description:

Cadazolid is a synthetic antibiotic compound that belongs to the class of oxazolidinones, which are known for their effectiveness against Gram-positive bacteria, including resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA). It is characterized by its mechanism of action, which involves the inhibition of bacterial protein synthesis by binding to the 50S ribosomal subunit. This action disrupts the translation process, ultimately leading to bacterial cell death. Cadazolid has been investigated for its potential use in treating various infections, particularly those caused by multidrug-resistant organisms. In terms of its chemical properties, cadazolid exhibits good oral bioavailability and has a favorable pharmacokinetic profile, making it a candidate for systemic infections. Additionally, it has shown a lower propensity for causing certain side effects commonly associated with other antibiotics in its class, such as peripheral neuropathy and myelosuppression. Ongoing research continues to evaluate its efficacy and safety in clinical settings, particularly for complicated skin and soft tissue infections.

Formula: C₂₉H₂₉F₂N₃O₈

InChI: InChI=1S/C29H29F2N3O8/c30-21-10-19-23(33(16-1-2-16)13-20(26(19)36)27(37)38)11-24(21)32-7-5-29(40,6-8-32)15-41-25-4-3-17(9-22(25)31)34-12-18(14-35)42-28(34)39/h3-4,9-11,13,16,18,35,40H,1-2,5-8,12,14-15H2,(H,37,38)/t18-/m1/s1

InChI key: InChIKey=XWFCFMXQTBGXQW-GOSISDBHSA-N

SMILES: O=C1C=2C(N(C=C1C(O)=O)C3CC3)=CC(=C(F)C2)N4CCC(COC5=C(F)C=C(C=C5)N6C[C@H](CO)OC6=O)(O)CC4

Synonyms:

• 1-Cyclopropyl-6-fluoro-7-[4-[[2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-3-oxazolidinyl]phenoxy]methyl]-4-hydroxy-1-piperidinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-7-[4-[[2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-3-oxazolidinyl]phenoxy]methyl]-4-hydroxy-1-piperidinyl]-1,4-dihydro-4-oxo-
• Cadazolid
• 1-Cyclopropyl-6-fluoro-7-[4-[[2-fluoro-4-((R)-5-hydroxymethyl-2-oxooxazolidin-3-yl)phenoxy]methyl]-4-hydroxypiperidin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• ACT 179811

Cadazolid

CAS: 1025097-10-2

Cadazolid (ACT-179811) is an oxazolidinone-type antibiotic, with activity against gram-positive bacteria, including Clostridium difficile.

Formula: C₂₉H₂₉F₂N₃O₈

Purity: 98.1% - 99.9%

Color and Shape: Solid

Molecular weight: 585.55

Ref: TM-T4020

Cadazolid

CAS: 1025097-10-2

Formula: C₂₉H₂₉F₂N₃O₈

Molecular weight: 585.57

Ref: 4Z-C-221001

Cadazolid

CAS: 1025097-10-2

Cadazolid is an investigational antibiotic, which is a synthetic oxazolidinone-cephalosporin hybrid, with a novel mechanism of action. It is engineered to disrupt bacterial protein synthesis by binding to the 50S ribosomal subunit, while also exerting strong bactericidal effects. This dual-action approach combines attributes of both linezolid and cephalosporins to target and disrupt essential bacterial processes.

Formula: C₂₉H₂₉F₂N₃O₈

Purity: Min. 95%

Molecular weight: 585.55 g/mol

Ref: 3D-ARB09710