CAS 1025687-58-4

r788

Description:

R788, also known by its chemical name, is a small molecule that acts as a selective inhibitor of the enzyme spleen tyrosine kinase (Syk). This compound has garnered attention in the field of medicinal chemistry due to its potential therapeutic applications, particularly in the treatment of autoimmune diseases and certain types of cancer. R788 exhibits characteristics such as good solubility in organic solvents and moderate stability under physiological conditions. Its mechanism of action involves the disruption of signaling pathways that are critical for the activation of immune cells, thereby modulating inflammatory responses. The compound has been studied in various preclinical and clinical settings, demonstrating efficacy in reducing disease symptoms in models of rheumatoid arthritis and other inflammatory conditions. Additionally, R788's pharmacokinetic profile suggests it can be administered orally, making it a convenient option for patients. As research continues, further insights into its safety, efficacy, and potential side effects are being explored to optimize its use in clinical applications.

Synonyms:

• Fostamatinib sodium

2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, sodium salt (1:2)

CAS: 1025687-58-4

Formula: C₂₃H₂₄FN₆Na₂O₉P

Purity: %

Color and Shape: Solid

Molecular weight: 624.4232

Ref: IN-DA008ST9

Sodium (6-((5-Fluoro-2-((3,4,5-Trimethoxyphenyl)Amino)Pyrimidin-4-Yl)Amino)-2,2-Dimethyl-3-Oxo-2,3-Dihydro-4H-Pyrido[3,2-B][1,4]Oxazin-4-Yl)Methyl Phosphate

CAS: 1025687-58-4

Sodium (6-((5-Fluoro-2-((3,4,5-Trimethoxyphenyl)Amino)Pyrimidin-4-Yl)Amino)-2,2-Dimethyl-3-Oxo-2,3-Dihydro-4H-Pyrido[3,2-B][1,4]Oxazin-4-Yl)Methyl Phosphate

Purity: 98+%

Molecular weight: 624.42g/mol

Ref: 54-PC108900

Fostamatinib Disodium

CAS: 1025687-58-4

Fostamatinib Disodium

Purity: ≥95%

Molecular weight: 624.42g/mol

Ref: 54-BUP07893

R788 disodium salt

CAS: 1025687-58-4

Ref: 7W-GW0002

Fostamatinib Disodium

CAS: 1025687-58-4

Formula: C₂₃H₂₆FN₆O₉P·2Na

Molecular weight: 580.47 2*22.99

Ref: 4Z-F-207010

Fostamatinib Disodium

CAS: 1025687-58-4

Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.

Formula: C₂₃H₂₄FN₆O₉P·2Na

Purity: 96.13% - 99.09%

Color and Shape: Solid

Molecular weight: 624.42

Ref: TM-T2605

R788 (Fostamatinib) Disodium

CAS: 1025687-58-4

R788 (Fostamatinib) Disodium is a drug that is used for the diagnosis of autoimmune diseases. It inhibits the activity of tyrosine kinases, which are enzymes that transmit signals in cells. Fostamatinib disodium has been shown to inhibit T-cell lymphomas in vivo and has been shown to have significant cytotoxicity against various leukemia cell lines. In vitro studies have shown that this drug is an inhibitor of effector proteins such as leukemia inhibitory factor and protein kinase C. The oral prodrug of R788 (fostamatinib) disodium has been found to be absorbed rapidly and to be glucuronide conjugated in humans. This drug also has pharmacokinetic properties that can be used to monitor its exposure in patients with autoimmune diseases and t-cell lymphomas.

Formula: C₂₃H₂₄FN₆O₉P·2Na

Purity: Min. 95%

Molecular weight: 624.42 g/mol

Ref: 3D-ARB68758