CAS 102601-58-1

N-cbz-gly-gly-arg 7-amido-4-*methylcoumarin hydro

Description:

N-Cbz-gly-gly-arg 7-amido-4-methylcoumarin hydro, identified by CAS number 102601-58-1, is a synthetic compound often utilized in biochemical research, particularly in the study of proteolytic enzymes. This compound features a coumarin moiety, which is known for its fluorescent properties, making it valuable in various assays and imaging techniques. The presence of the N-Cbz (carbobenzyloxy) group indicates that it is a protected amino acid derivative, which is commonly used to facilitate peptide synthesis. The gly-gly-arg sequence suggests that it is a peptide substrate, potentially useful for studying the specificity and activity of proteases. Its hydro designation implies that it may exist in a hydrated form or be involved in hydrolytic reactions. Overall, this compound's unique structural features and functional groups make it a significant tool in the field of biochemistry, particularly for applications involving enzyme kinetics and substrate specificity.

Formula: C₂₈H₃₄ClN₇O₇

InChI: InChI=1/C28H33N7O7.ClH/c1-17-12-25(38)42-22-13-19(9-10-20(17)22)34-26(39)21(8-5-11-31-27(29)30)35-24(37)15-32-23(36)14-33-28(40)41-16-18-6-3-2-4-7-18;/h2-4,6-7,9-10,12-13,21H,5,8,11,14-16H2,1H3,(H,32,36)(H,33,40)(H,34,39)(H,35,37)(H4,29,30,31);1H

SMILES: Cc1cc(=O)oc2cc(ccc12)N=C(C(CCCNC(=N)N)N=C(CN=C(CN=C(O)OCc1ccccc1)O)O)O.Cl

Synonyms:

• Z-Gly-Gly-Arg-AMC . HCl
• N-[(benzyloxy)carbonyl]glycylglycyl-N5-(diaminomethylidene)-N-(4-methyl-2-oxo-2H-chromen-7-yl)ornithinamide hydrochloride
• Z-Gly-Gly-Arg-7-Amino-4-Methylcoumarin

Z-Gly-Gly-Arg-AMC · HCl

CAS: 102601-58-1

Z-GGR-AMC has been used as substrate in a direct fluorometric assay of urokinase and tissue-type plasminogen activator as well as for assaying trypsin and thrombin.The substrate is used as thrombin substrate in the calibrated automated thrombogram (CAT), an automated test developed by Hemker et al., for determining hyper- and hypocoagulability. Z-GGR-AMC can also be used for determining the tryptic activity of proteasomes.

Formula: C₂₈H₃₃N₇O₇·HCl

Purity: > 99%

Color and Shape: White

Molecular weight: 616.07

Ref: 01-4002155

L-Argininamide, N-[(phenylmethoxy)carbonyl]glycylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, hydrochloride (1:1)

CAS: 102601-58-1

Formula: C₉H₁₀ClNO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 215.6336

Ref: IN-DA0007VN

Z-Gly-Gly-Arg-AMC HCl

CAS: 102601-58-1

Z-Gly-Gly-Arg-AMC HCl

Molecular weight: 616.07g/mol

Ref: 54-BIBA1003

N-CBZ-Glycyl-glycyl-L-arginine 7-Amido-4-methylcoumarin Hydrochloride

CAS: 102601-58-1

Applications N-CBZ-Glycyl-glycyl-L-arginine 7-Amido-4-methylcoumarin Hydrochloride is a fluorogenic substrate for uPA (urokinase).
References Zimmerman, M., et al. Proc. Natl. Acad. Sci. USA 75, 750 (1978);

Formula: C₂₈H₃₃N₇O₇·HCl

Color and Shape: Neat

Molecular weight: 579.60 + (36.46)

Ref: TR-C227058

Z-Gly-Gly-Arg-AMC·HCl

CAS: 102601-58-1

Z-Gly-Gly-Arg-AMC·HCl is a proteolytic enzyme that cleaves proteins at the carboxyl side of the amino acid arginine. It has been shown to have potential as a drug target and has been found to be active against carcinoma cell lines, but not normal cells. Z-Gly-Gly-Arg-AMC·HCl is activated by light and can be inhibited by natural compounds such as 2-aminoethoxydiphenyl borate. In addition, it specifically cleaves proteins at the carboxyl side of arginine residues, which makes it useful for studying protein degradation mechanisms in living cells and tissues.

Formula: C₂₈H₃₃N₇O₇·HCl

Purity: Min. 98%

Color and Shape: White Powder

Molecular weight: 616.07 g/mol

Ref: 3D-FG110492

Z-Glycyl-Glycyl-L-Arginine 7-Amido-4-Methylcoumarin Hydrochloride Salt extrapure, 95%

CAS: 102601-58-1

Formula: C₂₈H₃₃N₇O₇·HCl

Molecular weight: 616.07

Ref: SR-72998