CAS 1026016-84-1

(3S,11bS)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one

Description:

The chemical substance known as (3S,11bS)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one, with the CAS number 1026016-84-1, is a complex organic compound characterized by its unique bicyclic structure, which includes a quinolizinone moiety. This compound features multiple stereocenters, contributing to its chiral nature, which can influence its biological activity and interactions. The presence of methoxy groups indicates potential for increased lipophilicity, which may enhance its solubility in organic solvents. The branched alkyl substituent (2-methylpropyl) suggests that the compound may exhibit specific steric properties, potentially affecting its pharmacokinetics and receptor binding. As a member of the quinolizidine family, it may possess interesting pharmacological properties, although specific biological activities would require further investigation. Overall, this compound's structural complexity and functional groups suggest potential applications in medicinal chemistry, particularly in the development of novel therapeutic agents.

Formula: C₁₉H₂₇NO₃

InChI: InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/m0/s1

InChI key: InChIKey=MKJIEFSOBYUXJB-HOCLYGCPSA-N

SMILES: O(C)C=1C=C2[C@]3(N(C[C@H](CC(C)C)C(=O)C3)CCC2=CC1OC)[H]

Synonyms:

• (-)-Tbz
• (-)-Tetrabenazine
• (3S,11bS)-TBZ
• (3S,11bS)-Tetrabenazine
• 2H-benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahyd
• 2H-benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3s,11bs)-
• (3S,11bS)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one

(3S,11bS)-3-Isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one

CAS: 1026016-84-1

Formula: C₁₉H₂₇NO₃

Color and Shape: Solid

Molecular weight: 317.4226

Ref: IN-DA0007VK

(3S,11bS)-Tetrabenazine

CAS: 1026016-84-1

Formula: C₁₉H₂₇NO₃

Molecular weight: 317.43

Ref: 4Z-T-7843

(3S,11bS)-Tetrabenazine-d7

CAS: 1026016-84-1

Formula: C₁₉H₂₀D₇NO₃

Molecular weight: 324.47

Ref: 4Z-T-7845

(-)-Tetrabenazine (>75% ee)

Controlled Product

CAS: 1026016-84-1

Formula: C₁₉H₂₇NO₃

Color and Shape: Off-White

Molecular weight: 317.42

Ref: TR-T284023

(-)-Tetrabenazine-d3 (>75% ee)

Controlled Product

CAS: 1026016-84-1

Formula: C₁₉D₃H₂₄NO₃

Color and Shape: Neat

Molecular weight: 320.441

Ref: TR-T284024

(-)-Tetrabenazine-d3

Controlled Product

CAS: 1026016-84-1

(-)-Tetrabenazine-d3 is a synthetic enantiomer of tetrabenazine. It is an inhibitor of dopamine uptake and can be used in the treatment of Parkinson's disease. (-)-Tetrabenazine-d3 is a nucleophilic compound that binds to the dopamine transporter type 2 (DAT2) and inhibits its activity, which prevents the reuptake of dopamine from the synapse. This drug has been shown to be effective in reducing dyskinesias in animal models and humans with Parkinson's disease.

Formula: C₁₉H₂₄D₃NO₃

Purity: Min. 95%

Molecular weight: 320.44 g/mol

Ref: 3D-BRB01684