CAS 102676-47-1

Fadrozole

Description:

Fadrozole is a synthetic compound primarily recognized as an aromatase inhibitor, which means it inhibits the enzyme aromatase responsible for converting androgens to estrogens. This characteristic makes it significant in the treatment of hormone-dependent conditions, particularly certain types of breast cancer. The chemical structure of fadrozole includes a pyridine ring, contributing to its pharmacological properties. It is typically administered orally and has been studied for its potential in both human and veterinary medicine, particularly in the context of managing estrogen-related disorders. Fadrozole exhibits a relatively high affinity for the aromatase enzyme, leading to a decrease in estrogen levels in the body. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion, which are crucial for determining its therapeutic efficacy and safety profile. As with many pharmaceuticals, potential side effects may include hormonal imbalances and other related symptoms, necessitating careful monitoring during treatment. Overall, fadrozole represents an important tool in endocrine therapy, particularly in oncology.

Formula: C₁₄H₁₃N₃

InChI: InChI=1/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2

InChI key: InChIKey=CLPFFLWZZBQMAO-UHFFFAOYSA-N

SMILES: C(#N)C1=CC=C(C2N3C(CCC2)=CN=C3)C=C1

Synonyms:

• 4-(5,6,7,8-Tetrahydroimidazo[1,5-A]Pyridin-5-Yl)Benzonitrile
• Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo(1,5-a)pyridin-5-yl)-
• Ccris 8823
• Fadrozol
• Fadrozol [INN-Spanish]
• Fadrozole [INN]
• Fadrozolum
• Fadrozolum [INN-Latin]
• Imidazo[1,5-a]pyridine, benzonitrile deriv.
• Unii-H3988M64Pu
• Fadrozole
• Fadrozole
• CGS-169494
• CS-2710
• FAD 286)
• 4-(5，6，7，8-Tetrahydroimidazo[1，5-α]pyridin-5-y1)benzonitrile
• CGS-16949
• Afema
• Fadrozole Hydrochloride Hydrate
• FAD286
• 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridine-5-yl)benzonitrile
• 4-{5H,6H,7H,8H-iMidazo[1,5-a]pyridin-5-yl}benzonitrile
• 5,6,7,8-Tetrahydro-5-(4-cyanophenyl)imidazo[1,5-a]pyridine
• (CGS 16949A

Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-

CAS: 102676-47-1

Formula: C₁₄H₁₃N₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 223.2731

Ref: IN-DA00082Q

Fadrozole

CAS: 102676-47-1

Fadrozole

Purity: ≥95%

Molecular weight: 223.27g/mol

Ref: 54-BUP06394

Fadrozole

CAS: 102676-47-1

Formula: C₁₄H₁₃N₃

Molecular weight: 223.27

Ref: 7W-GP2690

Fadrozole

CAS: 102676-47-1

Fadrozole is a nonsteroidal aromatase inhibitor with potential antineoplastic activity(IC50 : 6.4 nM)

Formula: C₁₄H₁₃N₃

Purity: 99.47%

Color and Shape: Solid

Molecular weight: 223.27

Ref: TM-T7197

Fadrozole

CAS: 102676-47-1

Fadrozole is an inhibitor of the enzyme aromatase, which converts androgens to estrogens. It is used in combination with other drugs to treat breast cancer in postmenopausal women and prostate cancer in men. The molecular basis for the inhibitory properties of fadrozole is its ability to bind to the dinucleotide phosphate-binding site of aromatase, thereby inhibiting its activity. Fadrozole inhibits the production of estrogens by competitively binding to the enzyme's active site. The inhibitory effect of fadrozole on aromatase activity has been demonstrated in experimental models and provides a possible explanation for its use in combination with other drugs for breast and prostate cancer treatment.

Formula: C₁₄H₁₃N₃

Purity: Min. 95%

Molecular weight: 223.27 g/mol

Ref: 3D-CEA67647