CAS 1026987-94-9

DUPA(OtBu)-OH

Description:

DUPA(OtBu)-OH, with the CAS number 1026987-94-9, is a chemical compound characterized by its unique structure that includes a dipeptide-like backbone and a tert-butyl (OtBu) group. This compound is often utilized in biochemical research, particularly in studies involving peptide synthesis and drug development. Its structure allows for specific interactions with biological targets, making it valuable in medicinal chemistry. The presence of the tert-butyl group enhances its solubility and stability, which are crucial for various applications in organic synthesis and pharmaceutical formulations. Additionally, DUPA(OtBu)-OH may exhibit specific reactivity patterns typical of hydroxyl-containing compounds, such as participating in esterification or etherification reactions. Overall, its properties make it a versatile building block in the synthesis of more complex molecules and in the exploration of therapeutic agents.

Synonyms:

• 2-[3-(1,3-bis-tert-butoxycarbonylpropyl)ureido]pentanedioic acid 1-tert-butyl ester
• (S)-5-tert-butoxy-4-(3-((S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic acid

DUPA(OtBu)-OH

CAS: 1026987-94-9

DUPA(OtBu)-OH, a DUPA precursor, targets PSMA with high affinity (Ki=8nM) to deliver Docetaxel for prostate cancer therapy.

Formula: C₂₃H₄₀N₂O₉

Purity: 97.29%

Color and Shape: Solid

Molecular weight: 488.57

Ref: TM-T11122

L-Glutamic acid, N-[[[(1S)-3-carboxy-1-[(1,1-dimethylethoxy)carbonyl]propyl]amino]carbonyl]-, 1,5-bis(1,1-dimethylethyl) ester

CAS: 1026987-94-9

Formula: C₂₃H₄₀N₂O₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 488.5717

Ref: IN-DA000855

DUPA(OtBu)-OH

CAS: 1026987-94-9

DUPA(OtBu)-OH

Purity: ≥95%

Molecular weight: 488.57g/mol

Ref: 54-BUP09533

(S)-5-Tert-butoxy-4-(3-((s)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic Acid

Controlled Product

CAS: 1026987-94-9

Applications (S)-5-tert-Butoxy-4-(3-((s)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic Acid is used as a reactant in the synthesis of a DUPA-paclitaxel conjugate for antigen targeted therapy of prostate cancer.
References Lv, Qingzhi, et al.: Mol. Pharma., 15(5), 1842-1852 (2018)

Formula: C₂₃H₄₀N₂O₉

Color and Shape: Neat

Molecular weight: 488.57

Ref: TR-T205165

DUPA(OtBu)-OH

CAS: 1026987-94-9

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Formula: C₂₃H₄₀N₂O₉

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 488.57 g/mol

Ref: 3D-FD174919