CAS 102772-66-7

Pyridinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt

Description:

Pyridinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt, identified by CAS number 102772-66-7, is a complex organic compound characterized by its intricate molecular structure, which includes a pyridinium moiety and multiple functional groups such as thiazole, carboxylic acid, and amide functionalities. This compound is typically soluble in polar solvents due to its ionic nature, which arises from the presence of the inner salt formation. Its structure suggests potential biological activity, possibly as an antimicrobial or therapeutic agent, given the presence of thiazole and amino acid derivatives. The stereochemistry indicated by the (6R,7R) configuration may influence its biological interactions and pharmacokinetics. Overall, this compound exemplifies the diversity of synthetic organic chemistry, particularly in the design of molecules with potential pharmaceutical applications.

Formula: C₂₆H₃₀N₆O₇S₂

InChI: InChI=1S/C26H30N6O7S2/c1-25(2,3)38-23(37)26(4,5)39-30-16(15-13-41-24(27)28-15)19(33)29-17-20(34)32-18(22(35)36)14(12-40-21(17)32)11-31-9-7-6-8-10-31/h6-10,13,17,21H,11-12H2,1-5H3,(H3-,27,28,29,33,35,36)/b30-16-/t17-,21-/m1/s1

InChI key: InChIKey=KRTGQDGIPNXUGP-ZLQBWVSZSA-N

SMILES: C([O-])(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC(C(OC(C)(C)C)=O)(C)C)/C3=CSC(N)=N3)=O)C2=O)(SCC1C[N+]=4C=CC=CC4)[H]

Synonyms:

• Pyridinium, 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt
• Pyridinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt
• Ceftazidime tert-butyl ester
• Pyridinium, 1-[[7-[[(2-amino-4-thiazolyl)[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt, [6R-[6α,7β(Z)]]-
• 1-[[(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-[[2-(1,1-diMethylethoxy)-1,1-diMethyl-2-oxoethoxy]iMino]acetyl]aMino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]Methyl]pyridiniuM Inner Salt
• Ceftazidime Impurity E (EP) (Ceftazidime t-Butyl Ester )
• Ceftazidime Ep Impurity E
• CeftazidiMe t-Butyl Ester
• Ceftazidime N-2 Intermediate
• Ceftazidime impurity 5/Ceftazidime EP Impurity E/(6R,7R)-7-[[(2Z)-2-(2-aminothiazol-4-yl)-2-[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]acetyl]amino]-8-oxo-3-[(1-pyridinio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• Ceftazidime Impurity 5(Ceftazidime EP Impurity E)
• (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetamido)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• Ceftazidime Impurity D(EP)

Ceftazidime T-Butyl Ester

CAS: 102772-66-7

Ceftazidime T-Butyl Ester

Purity: 99%

Molecular weight: 602.68g/mol

Ref: 54-OR1027176

Ceftazidime EP Impurity E

CAS: 102772-66-7

Formula: C₂₆H₃₀N₆O₇S₂

Color and Shape: White To Off-White Solid

Molecular weight: 602.68

Ref: 4Z-C-10504

Ceftazidime t-Butyl Ester

Controlled Product

CAS: 102772-66-7

Impurity Ceftazidime EP Impurity E
Applications Ceftazidime t-Butyl Ester (Ceftazidime EP Impurity E) Ceftazidime t-Butyl ester is an impurity of Ceftazidime (C244100). Ceftazidime impurity C.
References Miyake, A., et al.: Antimicrob. Agents Chemother., 486, 182 (1989), Seibert, G., et al.: Arzneim.-Forsch., 33, 1084 (1983),

Formula: C₂₆H₃₀N₆O₇S₂

Color and Shape: Neat

Molecular weight: 602.68

Ref: TR-C244115

Ceftazidime t-butyl ester

CAS: 102772-66-7

Ceftazidime t-butyl ester is a prodrug of ceftazidime. It is a crystalline, stable form of the drug that can be dissolved in an organic solvent. Ceftazidime t-butyl ester has an average UV detection wavelength with a linear range of 200-600 nm and can be detected at a wavelength of 220 nm. This drug is used to treat infections caused by bacteria, including those that are resistant to other antibiotics, such as penicillin or ampicillin. Ceftazidime t-butyl ester has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex.

Formula: C₂₆H₃₀N₆O₇S₂

Purity: Min. 95%

Molecular weight: 602.68 g/mol

Ref: 3D-IC19872

Ceftazidime EP Impurity E

CAS: 102772-66-7

Formula: C₂₆H₃₀N₆O₇S₂

Molecular weight: 602.68

Ref: ST-EA-CP-C12005