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CAS 102783-24-4

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N-G,N-G'-dimethyl-L-arginine

Description:
N-G,N-G'-dimethyl-L-arginine, commonly referred to as asymmetrical dimethylarginine (ADMA), is a naturally occurring amino acid derivative that plays a significant role in various biological processes. It is a competitive inhibitor of nitric oxide synthase, which means it can impede the production of nitric oxide, a crucial signaling molecule involved in vascular function and blood pressure regulation. ADMA is synthesized in the body through the methylation of L-arginine, primarily in the endothelial cells. Elevated levels of ADMA are associated with cardiovascular diseases, as they can lead to endothelial dysfunction and reduced nitric oxide availability. The substance is soluble in water and exhibits basic properties due to the presence of the guanidinium group in its structure. Its biological significance has made it a subject of research in the context of cardiovascular health, metabolic disorders, and other conditions where nitric oxide signaling is disrupted. Overall, N-G,N-G'-dimethyl-L-arginine serves as an important biomarker and potential therapeutic target in various health-related studies.
Formula:C32H38N8O10S2
InChI:InChI=1/C8H18N4O2/c1-12(2)6(7(13)14)4-3-5-11-8(9)10/h6H,3-5H2,1-2H3,(H,13,14)(H4,9,10,11)
SMILES:CN(C)C(CCCNC(=N)N)C(=O)O
Synonyms:
  • (E)-N~5~-[amino(dimethylamino)methylidene]ornithine
  • (E)-N~5~-[amino(dimethylamino)methylidene]-L-ornithine
  • N~2~,N~2~-dimethylarginine
  • (2S)-2-amino-5-[(amino-dimethylamino-methylidene)amino]pentanoic acid
  • SDMA 2HABS
  • NG,NG-Dimethylarginine
  • N5-[(Dimethylamino)iminomethyl]-L-ornithine bis[4-[(4-hydroxyphenyl)azo]benzenesulfonate]
  • NG,N'G-DIMETHYL-L-ARGININE DI(P-HYDROXYAZOBENZENE-P'-SULFONATE)
  • ω,ω-Dimethylarginine
  • sdma
  • See more synonyms
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