CAS 102814-08-4: 2'-deoxyuridine 5'-triphosphate
Description:2'-Deoxyuridine 5'-triphosphate (dUTP) is a nucleotide that plays a crucial role in DNA synthesis and repair. It is a derivative of uridine, where the ribose sugar is modified to a deoxyribose, and it contains three phosphate groups attached to the 5' carbon. This structure allows dUTP to serve as a substrate for DNA polymerases during DNA replication. dUTP is also involved in the incorporation of uracil into DNA, which can lead to mutations if not properly regulated, as DNA typically contains thymine instead of uracil. The enzyme dUTPase hydrolyzes dUTP to dUMP and inorganic phosphate, thereby preventing the incorporation of uracil into DNA and maintaining genomic integrity. In addition to its biological significance, dUTP is utilized in various molecular biology techniques, including PCR and DNA sequencing, where it can be incorporated in place of dTTP to study the effects of uracil in DNA. Its CAS number, 102814-08-4, identifies it uniquely in chemical databases.
Formula:C9H15N2NaO14P3
InChI:InChI=1/C9H15N2O14P3.Na/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17;/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17);
- Synonyms:
- 2-Deoxyuridine-5-triphosphoric acid sodium salt
- dUTP-Na
- 2'-Deoxyuridine 5'-(Tetrahydrogen Triphosphate)
- 2,4(1H,3H)-pyrimidinedione, 1-[2-deoxy-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]pentofuranosyl]-, monosodium salt
- 2'-Deoxyuridine-5'-triphosphate,trisodium salt
- dUTP.Na3
