CAS 1028206-58-7

(SP-4-4)-[2-[2-(Amino-κN)ethyl]phenyl-κC]chloro[dicyclohexyl(2′,6′-dimethoxy[1,1′-biphenyl]-2-yl)phosphine-κP]palladium

Description:

The chemical substance known as "(SP-4-4)-[2-[2-(Amino-κN)ethyl]phenyl-κC]chloro[dicyclohexyl(2′,6′-dimethoxy[1,1′-biphenyl]-2-yl)phosphine-κP]palladium" with CAS number 1028206-58-7 is a palladium complex that features a chiral phosphine ligand. This compound is characterized by its coordination of palladium with a chloro ligand and a phosphine ligand that contains a dicyclohexyl group and a dimethoxy-substituted biphenyl moiety. The presence of the aminoethylphenyl group contributes to its potential applications in asymmetric catalysis, particularly in reactions such as cross-coupling and hydrogenation. The stereochemistry of the compound is significant, as it can influence the reactivity and selectivity in catalytic processes. Additionally, the complex's solubility, stability, and reactivity can be affected by the steric and electronic properties of the ligands attached to the palladium center. Overall, this compound represents a specialized class of organometallic chemistry with potential utility in synthetic organic chemistry.

Formula: C₃₄H₄₅ClNO₂PPd

InChI: InChI=1S/C26H35O2P.C8H10N.ClH.Pd/c1-27-23-17-11-18-24(28-2)26(23)22-16-9-10-19-25(22)29(20-12-5-3-6-13-20)21-14-7-4-8-15-21;9-7-6-8-4-2-1-3-5-8;;/h9-11,16-21H,3-8,12-15H2,1-2H3;1-4H,6-7,9H2;1H;/q;-1;;+2/p-1

InChI key: InChIKey=RUWSWVWKRCXWAA-UHFFFAOYSA-M

SMILES: [P](C1=C(C=CC=C1)C2=C(OC)C=CC=C2OC)([Pd+2]3([Cl-])[C-]=4C(CC[NH2]3)=CC=CC4)(C5CCCCC5)C6CCCCC6

Synonyms:

• (SP-4-4)-[2-[2-(Amino-κN)ethyl]phenyl-κC]chloro[dicyclohexyl(2′,6′-dimethoxy[1,1′-biphenyl]-2-yl)phosphine-κP]palladium
• Chloro(2-Dicyclohexylphosphino-2',6'-Dimethoxy-1,1'-Biphenyl)[2-(2-Aminoethylphenyl)]Palladium(Ii)
• Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II)methyl-t-butylether adduct
• Palladium, [2-[2-(amino-κN)ethyl]phenyl-κC]chloro[dicyclohexyl(2',6'-dimethoxy[1,1'-biphenyl]-2-yl)phosphine-κP]-, (SP-4-4)-
• Palladium, [2-[2-(amino-κN)ethyl]phenyl-κC]chloro[dicyclohexyl(2′,6′-dimethoxy[1,1′-biphenyl]-2-yl)phosphine-κP]-, (SP-4-4)-
• SPhos Palladacycle

Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct, min. 98% [SPhos Palladacycle Gen. 1]

CAS: 1028206-58-7

Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct, min. 98% [SPhos Palladacycle Gen. 1]

Formula: C₃₄H₄₅ClNO₂PPd

Purity: min. 98%

Color and Shape: white pwdr.

Molecular weight: 672.57

Ref: 08-46-0269

Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct

CAS: 1028206-58-7

Formula: C₃₄H₄₅ClNO₂PPd

Purity: 98%

Color and Shape: Solid

Molecular weight: 672.5734

Ref: IN-DA008VKX

Chloro(2-Dicyclohexylphosphino-2,6-Dimethoxy-1,1-Biphenyl)[2-(2-Aminoethylphenyl)]Palladium(II)

CAS: 1028206-58-7

Chloro(2-Dicyclohexylphosphino-2,6-Dimethoxy-1,1-Biphenyl)[2-(2-Aminoethylphenyl)]Palladium(II)

Purity: 98%

Molecular weight: 672.57g/mol

Ref: 54-IN10385

SPhos Pd G1

CAS: 1028206-58-7

Purity: 98%

Molecular weight: 670.18

Ref: 10-F551743

Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II)

Controlled Product

CAS: 1028206-58-7

Applications Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) has been used as catalyst in, the studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential;  Biaryl Phosphine Based Pd(II) Amido Complexes: The Effect of Ligand Structure on Reductive Elimination
References Fujimoto J., et al., Bioorg. Med. Chem.: 25, 3018-3033 (2017); Arrechea P. L., et al., J. Am. Chem. Soc.: 138, 12486-12493 (2016)

Formula: C₂₆H₃₅O₂P·C₈H₁₀N·C₅H₁₂O·Cl·Pd

Color and Shape: Neat

Molecular weight: 760.721

Ref: TR-C602200