CAS 1028268-32-7

Diethyl 2-(4-chlorobenzamido)-2-[(2-oxo-1,2-dihydroquinolin-4-yl)methyl]malonate

Description:

Diethyl 2-(4-chlorobenzamido)-2-[(2-oxo-1,2-dihydroquinolin-4-yl)methyl]malonate is a complex organic compound characterized by its multi-functional structure, which includes a malonate moiety, a chlorobenzamide group, and a quinoline derivative. The presence of the diethyl malonate indicates that it has ester functionalities, which can influence its reactivity and solubility. The 4-chlorobenzamide component introduces a halogen, which can enhance biological activity and affect the compound's electronic properties. Additionally, the quinoline structure contributes to potential pharmacological properties, as quinolines are known for their diverse biological activities, including antimicrobial and antimalarial effects. This compound may exhibit moderate to high lipophilicity due to its aromatic and aliphatic components, which can affect its bioavailability and interaction with biological systems. Overall, the unique combination of functional groups in this molecule suggests potential applications in medicinal chemistry, particularly in drug development. However, specific properties such as melting point, boiling point, and solubility would require empirical data for precise characterization.

Rebamipide Impurity 28

CAS: 1028268-32-7

Formula: C₂₄H₂₃ClN₂O₆

Molecular weight: 470.91

Ref: 4Z-R-085039

2-[(4-Chlorobenzoyl)amino]-2-[(1,2-dihydro-2-oxo-4-quinolinyl)methyl]-propanedioic Acid 1,3-Diethyl Ester-d4

Controlled Product

CAS: 1028268-32-7

Applications 2-[(4-Chlorobenzoyl)amino]-2-[(1,2-dihydro-2-oxo-4-quinolinyl)methyl]-propanedioic Acid 1,3-Diethyl Ester-d4 is an intermediate used in the synthesis of Rebamipide-d4 (R139002), which is labelled Rebamipide, which shows antiulcer activity in rats.
References Uchida, M., et al.: Chem. Pharm. Bull., 33, 3775 (1985), Yamasaki, K., et al.: Eur. J. Pharmacol., 142, 23 (1987),

Formula: C₂₄D₄H₁₉ClN₂O₆

Color and Shape: Neat

Molecular weight: 474.927

Ref: TR-C373832