CAS 1029044-16-3

Plx 3397

Description:

PLX 3397, with the CAS number 1029044-16-3, is a small molecule inhibitor primarily targeting the receptor tyrosine kinases (RTKs) such as c-KIT, PDGFR, and FLT3. It is notable for its role in cancer research, particularly in the treatment of various malignancies, including those associated with mutations in these kinases. PLX 3397 exhibits a selective inhibition profile, which helps to minimize off-target effects, making it a candidate for targeted therapy. The compound is typically administered orally and has been evaluated in clinical trials for its efficacy and safety in treating tumors. Its mechanism of action involves blocking the signaling pathways that promote tumor growth and survival, thereby inducing apoptosis in cancer cells. Additionally, PLX 3397 has shown potential in modulating the tumor microenvironment, which can enhance the effectiveness of other therapeutic agents. As with many investigational drugs, ongoing research continues to elucidate its full pharmacological profile and therapeutic potential.

Formula: C₂₀H₁₅ClF₃N₅

InChI: InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)

InChI key: InChIKey=JGWRKYUXBBNENE-UHFFFAOYSA-N

SMILES: C(C=1C=2C(NC1)=NC=C(Cl)C2)C=3C=CC(NCC=4C=CC(C(F)(F)F)=NC4)=NC3

Synonyms:

• Pexidartinib
• PLX3397 (Pexidartinib)
• PLX339
• PLX-3397
• N-[5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
• Pexidartinib (PLX3397)
• 5-((5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)
• 3-Pyridinemethanamine,N-[5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-

N-[5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine

CAS: 1029044-16-3

Formula: C₂₀H₁₅ClF₃N₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 417.8148

Ref: IN-DA0039N8

Pexidartinib

CAS: 1029044-16-3

Pexidartinib

Purity: 98%

Molecular weight: 417.81g/mol

Ref: 54-PC108988

Pexidartinib

CAS: 1029044-16-3

Pexidartinib

Purity: ≥98%

Molecular weight: 417.81g/mol

Ref: 54-BUP17149

Pexidartinib

CAS: 1029044-16-3

Formula: C₂₀H₁₅ClF₃N₅

Purity: ≥ 98.0%

Color and Shape: White to off-white powder or solid

Molecular weight: 417.81

Ref: 7W-GP8518

Pexidartinib (PLX3397)

CAS: 1029044-16-3

Formula: C₂₀H₁₅ClF₃N₅

Molecular weight: 417.82

Ref: 4Z-K-031070

Pexidartinib

CAS: 1029044-16-3

Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential

Formula: C₂₀H₁₅ClF₃N₅

Purity: 98.34% - 99.45%

Color and Shape: Solid

Molecular weight: 417.81

Ref: TM-T2115

Pexidartinib

CAS: 1029044-16-3

Inhibitor of CSF1R receptor

Formula: C₂₀H₁₅ClF₃N₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 417.81 g/mol

Ref: 3D-FP76492