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CAS 102932-28-5

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6-hydroxydoxazosin

Description:
6-Hydroxydoxazosin is a chemical compound that belongs to the class of quinazoline derivatives, primarily known for its role as an alpha-1 adrenergic antagonist. This substance is characterized by its hydroxyl group at the sixth position of the doxazosin structure, which may influence its pharmacological properties. It is typically used in the treatment of hypertension and benign prostatic hyperplasia due to its ability to relax vascular smooth muscle and improve urinary flow. The molecular structure of 6-hydroxydoxazosin includes a fused bicyclic ring system, which is common in many adrenergic blockers. Its solubility and stability can vary based on pH and solvent conditions, which are important factors in its formulation and therapeutic use. Additionally, the compound's pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for understanding its efficacy and safety profile in clinical applications. As with many pharmaceuticals, potential side effects and interactions with other medications should be considered when evaluating its use in treatment regimens.
Formula:C23H25N5O6
InChI:InChI=1/C23H25N5O6/c1-31-17-10-14-15(11-18(17)32-2)25-23(26-21(14)24)28-7-5-27(6-8-28)22(30)20-12-33-19-9-13(29)3-4-16(19)34-20/h3-4,9-11,20,29H,5-8,12H2,1-2H3,(H2,24,25,26)
SMILES:COc1cc2c(cc1OC)nc([nH]c2=N)N1CCN(CC1)C(=O)C1COc2cc(ccc2O1)O
Synonyms:
  • [4-(4-Amino-6,7-Dimethoxyquinazolin-2-Yl)Piperazin-1-Yl](6-Hydroxy-2,3-Dihydro-1,4-Benzodioxin-2-Yl)Methanone
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