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CAS 1029364-75-7

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8-Ethoxymoxifloxacin

Description:
8-Ethoxymoxifloxacin is a synthetic fluoroquinolone antibiotic, characterized by its broad-spectrum antibacterial activity. It is derived from moxifloxacin, which is known for its efficacy against a variety of Gram-positive and Gram-negative bacteria. The presence of the ethoxy group at the 8-position enhances its pharmacological properties, potentially improving its bioavailability and therapeutic effectiveness. This compound operates by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes crucial for DNA replication and repair, thereby preventing bacterial growth. In terms of physical properties, 8-Ethoxymoxifloxacin is typically a crystalline solid, soluble in organic solvents, and exhibits moderate stability under standard conditions. Its use in clinical settings is primarily focused on treating respiratory tract infections, skin infections, and other bacterial diseases. As with other fluoroquinolones, it may have associated side effects, including gastrointestinal disturbances and potential effects on tendon health. Overall, 8-Ethoxymoxifloxacin represents a valuable addition to the arsenal of antibiotics, particularly in the face of rising antibiotic resistance.
Formula:C22H26FN3O4
InChI:InChI=1/C22H26FN3O4/c1-2-30-21-18-14(20(27)15(22(28)29)10-26(18)13-5-6-13)8-16(23)19(21)25-9-12-4-3-7-24-17(12)11-25/h8,10,12-13,17,24H,2-7,9,11H2,1H3,(H,28,29)/t12-,17+/m0/s1
Synonyms:
  • 1-Cyclopropyl-8-ethoxy-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
  • 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-8-ethoxy-6-fluoro-4-oxo-quinoline-3-carboxylic acid
  • 1-Cyclopropyl-8-ethoxy-6-fluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid
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