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CAS 1029364-77-9

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8-Fluoro-6-methoxymoxifloxacin

Description:
8-Fluoro-6-methoxymoxifloxacin is a synthetic fluoroquinolone antibiotic, characterized by its broad-spectrum antibacterial activity. It is a derivative of moxifloxacin, featuring a fluorine atom at the 8-position and a methoxy group at the 6-position of the quinolone ring. This compound exhibits potent activity against a variety of Gram-positive and Gram-negative bacteria, making it effective in treating respiratory and urinary tract infections. The mechanism of action involves the inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and repair. Additionally, 8-Fluoro-6-methoxymoxifloxacin is known for its favorable pharmacokinetic properties, including good oral bioavailability and tissue penetration. Its safety profile is generally acceptable, although like other fluoroquinolones, it may be associated with potential side effects such as tendonitis or tendon rupture, particularly in certain populations. Overall, this compound represents a valuable option in the arsenal of antibiotics, particularly in the context of increasing antibiotic resistance.
Formula:C21H24FN3O4
InChI:InChI=1/C21H24FN3O4/c1-29-16-7-13-18(25(12-4-5-12)9-14(20(13)26)21(27)28)17(22)19(16)24-8-11-3-2-6-23-15(11)10-24/h7,9,11-12,15,23H,2-6,8,10H2,1H3,(H,27,28)/t11-,15+/m0/s1
Synonyms:
  • 1-cyclopropyl-8-fluoro-6-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
  • 1-Cyclopropyl-8-fluoro-6-methoxy-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid
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