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CAS 1029872-54-5

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Vemurafenib

Description:
Vemurafenib is a small molecule drug primarily used in the treatment of certain types of melanoma, particularly those with the BRAF V600E mutation. It functions as a selective inhibitor of the mutated BRAF protein, which is involved in the MAPK signaling pathway that promotes cell growth and division. The chemical formula of vemurafenib is C23H22F2N4O3S, and it has a molecular weight of approximately 489.51 g/mol. This compound is characterized by its unique structure, which includes a pyrimidine core and a sulfonamide group, contributing to its specificity and efficacy against cancer cells harboring the BRAF mutation. Vemurafenib is typically administered orally and has been shown to improve survival rates in patients with advanced melanoma. However, it may also lead to side effects, including skin rash, joint pain, and potential for secondary skin cancers. Its development marked a significant advancement in targeted cancer therapies, highlighting the importance of personalized medicine in oncology.
Formula:C23H18ClF2N3O3S
InChI:InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
InChI key:InChIKey=GPXBXXGIAQBQNI-UHFFFAOYSA-N
SMILES:C(=O)(C=1C=2C(NC1)=NC=C(C2)C3=CC=C(Cl)C=C3)C4=C(F)C(NS(CCC)(=O)=O)=CC=C4F
Synonyms:
  • 1-Propanesulfonamide, N-[3-[[5-(4-Chlorophenyl)-1H-Pyrrolo[2,3-B]Pyridin-3-Yl]Carbonyl]-2,4-Difluorophenyl]-
  • N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide
  • N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
  • Plx 4032
  • Plx-4032 (RG7024)
  • Propane-1-sulfonic acid [3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]amide
  • Rg 7204
  • Ro 51-85426
  • Ro 5185426
  • Zelboraf
  • Vemurafenib
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Found 4 products.