CAS 10300-27-3

3′-O-Methylguanosine

Description:

3′-O-Methylguanosine is a modified nucleoside that plays a significant role in various biological processes, particularly in RNA metabolism. It consists of a guanine base attached to a ribose sugar, with a methyl group added to the 3′ hydroxyl position of the ribose. This modification can influence the stability and function of RNA molecules, affecting processes such as splicing, translation, and the overall regulation of gene expression. 3′-O-Methylguanosine is often found in the cap structure of eukaryotic mRNAs, contributing to mRNA stability and protection from degradation. Its presence can also enhance the efficiency of translation by facilitating the recognition of mRNA by ribosomes. The compound is soluble in water and exhibits typical nucleoside properties, including the ability to form hydrogen bonds and participate in base pairing. Due to its biological significance, 3′-O-Methylguanosine is of interest in research related to gene regulation, RNA processing, and the development of therapeutic agents targeting RNA.

Formula: C₁₁H₁₅N₅O₅

InChI: InChI=1S/C11H15N5O5/c1-20-7-4(2-17)21-10(6(7)18)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1

InChI key: InChIKey=UYARPHAXAJAZLU-KQYNXXCUSA-N

SMILES: O=C1C2=C(N(C=N2)[C@H]3[C@H](O)[C@H](OC)[C@@H](CO)O3)NC(N)=N1

Synonyms:

• 3'-O-Methylguanosine
• 3-Omg
• Nsc 106541
• Guanosine, 3'-O-methyl-
• 2-amino-9-(3-O-methylpentofuranosyl)-3,9-dihydro-6H-purin-6-one
• 2-amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]-3H-purin-6-one

2-amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]-3H-purin-6-one

CAS: 10300-27-3

Formula: C₁₁H₁₅N₅O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 297.2673

Ref: IN-DA008SO6

3''-O-Methylguanosine

CAS: 10300-27-3

Formula: C₁₁H₁₅N₅O₅

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 297.27

Ref: 7W-GN3227

3’-O-Methyl guanosine

CAS: 10300-27-3

3’-O-Methyl guanosine

Purity: ≥98%

Molecular weight: 297.27g/mol

Ref: 54-BUP11348

3'-O-Methylguanosine

CAS: 10300-27-3

3'-O-Methylguanosine

Purity: 98%

Molecular weight: 297.27g/mol

Ref: 54-OR1029410

3'-O-Methyl guanosine

CAS: 10300-27-3

Nucleoside Derivatives –3’-Modified nucleoside

Formula: C₁₁H₁₅N₅O₅

Purity: 99.95%

Color and Shape: Solid

Molecular weight: 297.27

Ref: TM-TNU0157

3'-O-Methyl Guanosine

CAS: 10300-27-3

Formula: C₁₁H₁₅N₅O₅

Molecular weight: 297.27

Ref: 4Z-G-2422

3'-O-Methylguanosine

CAS: 10300-27-3

3'-O-Methylguanosine is a nucleoside that is found in the guanine molecule and has been shown to have inhibitory properties against malignant brain tumors. 3'-O-Methylguanosine blocks the synthesis of DNA, RNA, and peptide hormones. It also inhibits the growth of erythromycin-resistant strains of bacteria. The kinetic data for 3'-O-Methylguanosine was obtained from experiments with leukemic mice and carcinoma cell lines. The enzyme glut1 regulates the rate of metabolism of 3'-O-Methylguanosine. It is metabolized by dehydroascorbic acid reductase to 3'-deoxyadenosine monophosphate (dAMP) and then to adenosine monophosphate (AMP). The optimum pH for this reaction is 7.3 at 37 degrees Celsius.

Formula: C₁₁H₁₅N₅O₅

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 297.27 g/mol

Ref: 3D-NM06232

2-AMINO-9-[(2R,3R,4S,5R)-3-HYDROXY-5-(HYDROXYMETHYL)-4-METHOXYOXOLAN-2-YL]-3H-PURIN-6-ONE

CAS: 10300-27-3

Formula: C₁₁H₁₅N₅O₅

Purity: 98%

Molecular weight: 297.271

Ref: 10-F513025