CAS 103026-83-1

Dehydro Nisoldipine

Description:

Dehydro Nisoldipine is a chemical compound that belongs to the class of dihydropyridine calcium channel blockers, primarily used in the treatment of hypertension and angina. It is characterized by its ability to selectively inhibit calcium influx through L-type calcium channels, leading to vasodilation and reduced blood pressure. The compound is typically administered in its racemic form and exhibits a high degree of lipophilicity, which enhances its absorption and bioavailability. Dehydro Nisoldipine has a relatively long half-life, allowing for once-daily dosing in clinical settings. Its pharmacological profile includes not only antihypertensive effects but also potential cardioprotective benefits. The compound is generally well-tolerated, though it may cause side effects such as peripheral edema, headache, and flushing. As with other calcium channel blockers, caution is advised in patients with certain cardiovascular conditions. Overall, Dehydro Nisoldipine represents an important therapeutic option in the management of cardiovascular diseases.

Formula: C₂₀H₂₂N₂O₆

Synonyms:

• 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl 5-(2-Methylpropyl) Ester

Nisoldipine USP Related Compound D (Dehydro Nisoldipine)

CAS: 103026-83-1

Formula: C₂₀H₂₂N₂O₆

Molecular weight: 386.41

Ref: 4Z-N-093

3-Isobutyl 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate

CAS: 103026-83-1

3-Isobutyl 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate

Purity: 98%

Ref: 54-OR1036741

Nisoldipine USP Related Compound D-d6 (Dehydro Nisoldipine-d6)

CAS: 103026-83-1

Formula: C₂₀H₁₆D₆N₂O₆

Molecular weight: 392.44

Ref: 4Z-N-094

Dehydro Nisoldipine

Controlled Product

CAS: 103026-83-1

Applications A metabolite of Nisoldipine (N489125).
References Grossi, P., et al.: Xenobiotica, 22, 899 (1992), Hayase, N., et al.: J. Pharm. Sci., 83, 532 (1994), Barlett, M., et al.: J. Pharm. Biomed. Anal., 18, 335 (1998), Nayler, W., et al.: J. Clin. Basic Cardiol., 2, 155 (1999), Mielcarek, J., et al.: J. Pharm. Biomed. Anal., 24, 71 (2000),

Formula: C₂₀H₂₂N₂O₆

Color and Shape: Neat

Molecular weight: 386.40

Ref: TR-D229900

Nisoldipine USP Related Compound D

CAS: 103026-83-1

Formula: C₂₀H₂₂N₂O₆

Molecular weight: 386.4

Ref: ST-EA-CP-N32012

Nisoldipine Related Compound D (3-Isobutyl 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate) (DISCONTINUED)

CAS: 103026-83-1

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₂₀H₂₂N₂O₆

Color and Shape: Pale Yellow Solid

Molecular weight: 386.14779

Ref: 45-1464158