CAS 103060-53-3: Daptomycin

Description: Daptomycin is a cyclic lipopeptide antibiotic primarily used to treat infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). It is produced by the fermentation of the bacterium Streptomyces roseosporus. Daptomycin exhibits a unique mechanism of action by binding to the bacterial cell membrane, leading to depolarization, disruption of essential cellular processes, and ultimately cell death. This antibiotic is typically administered intravenously and is known for its efficacy against complicated skin and skin structure infections, as well as bacteremia and endocarditis. Daptomycin is characterized by its high molecular weight and a complex structure that includes a fatty acid tail, which is crucial for its membrane-targeting properties. It is generally well-tolerated, although potential side effects may include muscle pain and elevated creatine phosphokinase levels. Due to its specific action against Gram-positive organisms, daptomycin is an important therapeutic option in the management of resistant bacterial infections.

Formula: C₇₂H₁₀₁N₁₇O₂₆

InChI: InChI=1/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35-,36-,37-,43+,44+,45+,46+,47+,48+,49+,50-,60+,61+/m1/s1

Synonyms:

• (3S)-3-{[(2S)-4-amino-2-{[(2S)-2-(decanoylamino)-3-(1H-indol-3-yl)propanoyl]amino}-4-oxobutanoyl]amino}-4-{[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(1R)-2-carboxy-1-methylethyl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]amino}-4-oxobutanoic acid
• (3S)-3-{[(2S)-4-Amino-2-{[(2S)-2-(decanoylamino)-3-(1H-indol-3-yl)propanoyl]amino}-4-oxobutanoyl]amino}-4-{[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(1R)-2-carboxy-1-methylethyl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]amino}-4-oxobutans?ure
• acide (3S)-3-{[(2S)-4-amino-2-{[(2S)-2-(décanoylamino)-3-(1H-indol-3-yl)propanoyl]amino}-4-oxobutanoyl]amino}-4-{[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophényl)-2-oxoéthyl]-24-(3-aminopropyl)-15,21-bis(carboxyméthyl)-6-[(1R)-2-carboxy-1-méthyléthyl]-9-(hydroxyméthyl)-18,31-diméthyl-2,5,8,11,14,17,20,23,26,29-décaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohéntriacontan-30-yl]amino}-4-oxobutano?que
• Cidecin
• Deptomycin
• L-alpha-asparagine, N-(1-oxodecyl)-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(1R)-2-carboxy-1-methylethyl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacont-30-yl]-
• Ly146032
• N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(1R)-2-carboxy-1-methylethyl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
• N-Decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
• Benzenebutanoic acid, N-(1-oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-, (13→4)-lactone, (αS)-
• Cubicin
• Dapcin
• Daptomicina
• Daptomycine
• Daptomycinum
• Ly 146032
• N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-(αS)-α,2-diamino-γ-oxobenzenebutanoic acid (13→4)-lactone

Daptomycin

CAS: 103060-53-3

• Formula: C₇₂H₁₀₁N₁₇O₂₆
• Purity: >94.0%(HPLC)(N)
• Color and Shape: White to Yellow to Orange powder to crystal
• Molecular weight: 1,620.69

Daptomycin

CAS: 103060-53-3

• Formula: C₇₂H₁₀₁N₁₇O₂₆
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 1620.6706399999994

Daptomycin

CAS: 103060-53-3

• Formula: C₇₂H₁₀₁N₁₇O₂₆
• Purity: (HPLC) ≥ 92.0%
• Color and Shape: Pale yellow to beige powder
• Molecular weight: 1620.7

Daptomycin

CAS: 103060-53-3

• Formula: C₇₂H₁₀₁N₁₇O₂₆
• Purity: By hplc: 96.29% (Typical Value in Batch COA)
• Color and Shape: pale yellow crystalline powder
• Molecular weight: 1,620.67g/mol

Daptomycin

CAS: 103060-53-3

• Formula: C₇₂H₁₀₁N₁₇O₂₆
• Color and Shape: Pale Yellow Solid
• Molecular weight: 1620.69

Daptomycin

CAS: 103060-53-3

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₇₂H₁₀₁N₁₇O₂₆
• Color and Shape: White to brown, Powder
• Molecular weight: 1620.69

Daptomycin

CAS: 103060-53-3

Daptomycin (LY146032) is a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.

• Formula: C₇₂H₁₀₁N₁₇O₂₆
• Purity: 100% - 99.61%
• Color and Shape: White Powder
• Molecular weight: 1620.67

Daptomycin

CAS: 103060-53-3

Applications Daptomycin is a Cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; …

• Formula: C₇₂H₁₀₁N₁₇O₂₆
• Color and Shape: Light Yellow
• Molecular weight: 1620.67

Daptomycin

CAS: 103060-53-3

Daptomycin is a cyclic lipopeptide that disrupts cell membrane potential and causes leakage from the …

• Formula: C₇₂H₁₀₁N₁₇O₂₆
• Purity: Min. 93 Area-%
• Color and Shape: Brown White Powder
• Molecular weight: 1,620.67 g/mol