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Daptomycin

CAS 103060-53-3: Daptomycin

Description:Daptomycin is a cyclic lipopeptide antibiotic primarily used to treat infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). It is produced by the fermentation of the bacterium Streptomyces roseosporus. Daptomycin exhibits a unique mechanism of action by binding to the bacterial cell membrane, leading to depolarization, disruption of essential cellular processes, and ultimately cell death. This antibiotic is typically administered intravenously and is known for its efficacy against complicated skin and skin structure infections, as well as bacteremia and endocarditis. Daptomycin is characterized by its high molecular weight and a complex structure that includes a fatty acid tail, which is crucial for its membrane-targeting properties. It is generally well-tolerated, although potential side effects may include muscle pain and elevated creatine phosphokinase levels. Due to its specific action against Gram-positive organisms, daptomycin is an important therapeutic option in the management of resistant bacterial infections.

Formula:C72H101N17O26

InChI:InChI=1/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35-,36-,37-,43+,44+,45+,46+,47+,48+,49+,50-,60+,61+/m1/s1

  • Synonyms:
  • (3S)-3-{[(2S)-4-amino-2-{[(2S)-2-(decanoylamino)-3-(1H-indol-3-yl)propanoyl]amino}-4-oxobutanoyl]amino}-4-{[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(1R)-2-carboxy-1-methylethyl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]amino}-4-oxobutanoic acid
  • (3S)-3-{[(2S)-4-Amino-2-{[(2S)-2-(decanoylamino)-3-(1H-indol-3-yl)propanoyl]amino}-4-oxobutanoyl]amino}-4-{[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(1R)-2-carboxy-1-methylethyl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]amino}-4-oxobutans?ure
  • acide (3S)-3-{[(2S)-4-amino-2-{[(2S)-2-(décanoylamino)-3-(1H-indol-3-yl)propanoyl]amino}-4-oxobutanoyl]amino}-4-{[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophényl)-2-oxoéthyl]-24-(3-aminopropyl)-15,21-bis(carboxyméthyl)-6-[(1R)-2-carboxy-1-méthyléthyl]-9-(hydroxyméthyl)-18,31-diméthyl-2,5,8,11,14,17,20,23,26,29-décaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohéntriacontan-30-yl]amino}-4-oxobutano?que
  • Cidecin
  • Deptomycin
  • L-alpha-asparagine, N-(1-oxodecyl)-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(1R)-2-carboxy-1-methylethyl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacont-30-yl]-
  • Ly146032
  • N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(1R)-2-carboxy-1-methylethyl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
  • N-Decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
  • Benzenebutanoic acid, N-(1-oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-, (13→4)-lactone, (αS)-
  • See more synonyms
  • Cubicin
  • Dapcin
  • Daptomicina
  • Daptomycine
  • Daptomycinum
  • Ly 146032
  • N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-(αS)-α,2-diamino-γ-oxobenzenebutanoic acid (13→4)-lactone
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Daptomycin

CAS:103060-53-3

Ref: 3B-D4229

100mg113.00 €
Estimated delivery in United States, on Wednesday 19 Feb 2025
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Daptomycin

CAS:103060-53-3

Ref: AC-46137

100mg153.00 €
500mg531.00 €
Estimated delivery in United States, on Monday 24 Feb 2025
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Ref: IN-DA008RA9

1g472.00 €
5gTo inquire
10gTo inquire
10mg53.00 €
50mg117.00 €
100mg138.00 €
250mg197.00 €
Estimated delivery in United States, on Wednesday 26 Feb 2025
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Daptomycin

CAS:103060-53-3

Ref: 7W-GA1723

5mg42.00 €
25mg84.00 €
100mg195.00 €
Estimated delivery in United States, on Thursday 27 Feb 2025
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Daptomycin

CAS:103060-53-3

Ref: 4Z-PD-122001

10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Thursday 27 Feb 2025
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Daptomycin

CAS:103060-53-3

Ref: TM-T1665

10mg50.00 €
25mg67.00 €
50mg87.00 €
100mg165.00 €
200mg252.00 €
1mL*10mM (DMSO)55.00 €
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Daptomycin

CAS:103060-53-3

Ref: 54-BID1023

1g1,117.00 €
100mg179.00 €
500mg629.00 €
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Daptomycin

CAS:103060-53-3

Ref: TR-D193350

1g606.00 €
100mg108.00 €
250mg215.00 €
Estimated delivery in United States, on Monday 10 Mar 2025
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Daptomycin

CAS:103060-53-3

Ref: 3D-AD15943

1g1,168.00 €
2g2,057.00 €
5g3,909.00 €
250mg520.00 €
500mg769.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Daptomycin Impurity 1 Sodium Salt

CAS:103060-53-3

Ref: TR-D194353

500µgDiscontinuedRequest information
2500µgDiscontinuedRequest information
Discontinued product
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