CAS 103129-81-3: (+)-Amlodipine
Description:(+)-Amlodipine is a dihydropyridine calcium channel blocker primarily used in the treatment of hypertension and angina. It is characterized by its ability to selectively inhibit calcium ions from entering vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced blood pressure. The compound is a chiral molecule, with the (+) designation indicating its specific optical activity. Its molecular formula typically consists of carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its pharmacological properties. (+)-Amlodipine is known for its long half-life, allowing for once-daily dosing, which enhances patient compliance. It is generally well-tolerated, with common side effects including peripheral edema, headache, and fatigue. The substance is often formulated as a salt, such as amlodipine besylate, to improve its solubility and bioavailability. As a member of the calcium channel blocker class, it plays a crucial role in cardiovascular therapy, helping to manage conditions related to high blood pressure and chest pain.
Formula:C20H25ClN2O5
InChI:InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/t17-/m1/s1
InChI key:InChIKey=HTIQEAQVCYTUBX-QGZVFWFLSA-N
SMILES:O=C(OC)C1=C(NC(=C(C(=O)OCC)C1C=2C=CC=CC2Cl)COCCN)C
- Synonyms:
- (+)-Amlodipine
- (R)-(+)-Amlodipine
- (R)-3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
- 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4R)-
- 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (R)-
- 3-ethyl 5-methyl (4R)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
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(R)-Amlodipine (3-ethyl 5-methyl (R)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate)
Ref: 45-1A01970
25mg | 1,104.00 € |
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(R)-Amlodipine
Ref: 4Z-A-084
5mg | To inquire | ||
10mg | To inquire | ||
25mg | To inquire | ||
50mg | To inquire | ||
100mg | To inquire |
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(R)-Amlodipine
Controlled ProductRef: TR-A633490
1mg | 272.00 € | ||
10mg | 1,803.00 € |
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(R)-Amlodipine
Ref: TM-T21265
25mg | 1,444.00 € | ||
50mg | 1,882.00 € | ||
100mg | 2,375.00 € |
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(R)-Amlodipine
Ref: 3D-DEA12981
1g | 1,690.00 € | ||
5g | 3,630.00 € | ||
10g | 5,446.00 € |