CAS 103129-82-4

(-)-Amlodipine

Description:

(-)-Amlodipine is a calcium channel blocker primarily used in the treatment of hypertension and angina. It is a dihydropyridine derivative, characterized by its ability to selectively inhibit the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac muscle. This action leads to vasodilation, reducing peripheral vascular resistance and lowering blood pressure. The compound is typically administered as its besylate salt form, which enhances its solubility and bioavailability. (-)-Amlodipine is known for its long half-life, allowing for once-daily dosing, and it exhibits a racemic mixture, with the (-)-enantiomer being the active form. Its molecular structure includes a 1,4-dihydropyridine ring, a phenyl group, and a piperidine moiety, contributing to its pharmacological properties. Common side effects may include peripheral edema, headache, and fatigue. As with any medication, it is essential to consider contraindications and interactions with other drugs when prescribing (-)-Amlodipine.

Formula: C₂₀H₂₅ClN₂O₅

InChI: InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/t17-/m0/s1

InChI key: InChIKey=HTIQEAQVCYTUBX-KRWDZBQOSA-N

SMILES: C(OCC)(=O)C=1[C@H](C(C(OC)=O)=C(C)NC1COCCN)C2=C(Cl)C=CC=C2

Synonyms:

• (-)-Amlodipine
• (4S)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
• 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-
• 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (S)-
• 3-Ethyl 5-methyl (4S)-2-((2-aminoethoxy)methyl)-4-(2-
• 3-ethyl 5-methyl (4R)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate (1:1)
• 3-ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• Levamlodipine
• Levamlodipine besylate
• Levoamlodipine
• Levoamlodipine Besylate
• Lodien
• chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• l-Amlodipine

Levamlodipine (3-ethyl 5-methyl (S)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate)

CAS: 103129-82-4

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₂₀H₂₅ClN₂O₅

Color and Shape: Off-White Solid

Molecular weight: 408.1452

Ref: 45-1A01960

(4S)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester

CAS: 103129-82-4

Formula: C₂₀H₂₅ClN₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 408.8759

Ref: IN-DA00327Q

Levamlodipine

CAS: 103129-82-4

Levamlodipine (S-amlodipine) belongs to the dihydropyridine group of calcium channel blockers.

Formula: C₂₀H₂₅ClN₂O₅

Purity: 97.21%

Color and Shape: White Crystal Powder

Molecular weight: 408.88

Ref: TM-T1545

Levamlodipine

CAS: 103129-82-4

Levamlodipine

Purity: ≥95%

Molecular weight: 408.88g/mol

Ref: 54-BUP15737

(S)-Amlodipine

CAS: 103129-82-4

(S)-Amlodipine

Purity: 99%

Molecular weight: 408.88g/mol

Ref: 54-OR1024552

(S)-Amlodipine

CAS: 103129-82-4

Formula: C₂₀H₂₅ClN₂O₅

Color and Shape: White To Off-White Solid

Molecular weight: 408.88

Ref: 4Z-A-085

(S)-Amlodipine

CAS: 103129-82-4

Formula: C₂₀H₂₅ClN₂O₅

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 408.88

Ref: 3B-A3608

(S)-Amlodipine

Controlled Product

CAS: 103129-82-4

Applications (S)-Enantiomer of Amlodipine (A633495). A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.
References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986), Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987), Haria, M., et al.: Drugs, 50, 560 (1995),

Formula: C₂₀H₂₅ClN₂O₅

Color and Shape: Neat

Molecular weight: 408.88

Ref: TR-A633491

Levamlodipine

CAS: 103129-82-4

Levamlodipine is a calcium channel blocker that is used to treat hypertension or high blood pressure. It prevents the entry of calcium into the cell by blocking voltage-gated calcium channels. Levamlodipine has been shown to be safe and effective in lowering blood pressure in patients with hypertension. The drug is not metabolized and can be detected in the blood for up to 24 hours after administration. Levamlodipine besylate, the active form of levamlodipine, is converted into its active form by esterases and glucuronidases in the liver and kidneys. This conversion takes place at a constant rate, resulting in a concentration–time curve that can be described using mathematical models.

Formula: C₂₀H₂₅ClN₂O₅

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 408.88 g/mol

Ref: 3D-FL174858