CAS 103129-82-4: (-)-Amlodipine
Description:(-)-Amlodipine is a calcium channel blocker primarily used in the treatment of hypertension and angina. It is a dihydropyridine derivative, characterized by its ability to selectively inhibit the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac muscle. This action leads to vasodilation, reducing peripheral vascular resistance and lowering blood pressure. The compound is typically administered as its besylate salt form, which enhances its solubility and bioavailability. (-)-Amlodipine is known for its long half-life, allowing for once-daily dosing, and it exhibits a racemic mixture, with the (-)-enantiomer being the active form. Its molecular structure includes a 1,4-dihydropyridine ring, a phenyl group, and a piperidine moiety, contributing to its pharmacological properties. Common side effects may include peripheral edema, headache, and fatigue. As with any medication, it is essential to consider contraindications and interactions with other drugs when prescribing (-)-Amlodipine.
Formula:C20H25ClN2O5
InChI:InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/t17-/m0/s1
InChI key:InChIKey=HTIQEAQVCYTUBX-KRWDZBQOSA-N
SMILES:O=C(OC)C1=C(NC(=C(C(=O)OCC)C1C=2C=CC=CC2Cl)COCCN)C
- Synonyms:
- (-)-Amlodipine
- (4S)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
- 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-
- 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (S)-
- 3-Ethyl 5-methyl (4S)-2-((2-aminoethoxy)methyl)-4-(2-
- 3-ethyl 5-methyl (4R)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate (1:1)
- 3-ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
- Levamlodipine
- Levamlodipine besylate
- Levoamlodipine
- See more synonyms
- Levoamlodipine Besylate
- Lodien
- chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
- l-Amlodipine
- (S)-(-)-Amlodipine