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(-)-Amlodipine

CAS 103129-82-4: (-)-Amlodipine

Description:(-)-Amlodipine is a calcium channel blocker primarily used in the treatment of hypertension and angina. It is a dihydropyridine derivative, characterized by its ability to selectively inhibit the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac muscle. This action leads to vasodilation, reducing peripheral vascular resistance and lowering blood pressure. The compound is typically administered as its besylate salt form, which enhances its solubility and bioavailability. (-)-Amlodipine is known for its long half-life, allowing for once-daily dosing, and it exhibits a racemic mixture, with the (-)-enantiomer being the active form. Its molecular structure includes a 1,4-dihydropyridine ring, a phenyl group, and a piperidine moiety, contributing to its pharmacological properties. Common side effects may include peripheral edema, headache, and fatigue. As with any medication, it is essential to consider contraindications and interactions with other drugs when prescribing (-)-Amlodipine.

Formula:C20H25ClN2O5

InChI:InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/t17-/m0/s1

InChI key:InChIKey=HTIQEAQVCYTUBX-KRWDZBQOSA-N

SMILES:O=C(OC)C1=C(NC(=C(C(=O)OCC)C1C=2C=CC=CC2Cl)COCCN)C

  • Synonyms:
  • (-)-Amlodipine
  • (4S)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
  • 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-
  • 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (S)-
  • 3-Ethyl 5-methyl (4S)-2-((2-aminoethoxy)methyl)-4-(2-
  • 3-ethyl 5-methyl (4R)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate (1:1)
  • 3-ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Levamlodipine
  • Levamlodipine besylate
  • Levoamlodipine
  • See more synonyms
  • Levoamlodipine Besylate
  • Lodien
  • chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
  • l-Amlodipine
  • (S)-(-)-Amlodipine
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Levamlodipine (3-ethyl 5-methyl (S)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate)

CAS:103129-82-4

Ref: 45-1A01960

25mg981.00 €
Estimated delivery in United States, on Tuesday 4 Mar 2025
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(4S)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester

CAS:103129-82-4

Ref: IN-DA00327Q

1g33.00 €
5g70.00 €
25g145.00 €
100g634.00 €
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Levamlodipine

CAS:103129-82-4

Ref: TM-T1545

10mg42.00 €
25mg70.00 €
50mg89.00 €
100mg125.00 €
200mg177.00 €
500mg299.00 €
1mL*10mM (DMSO)47.00 €
Estimated delivery in United States, on Wednesday 5 Mar 2025
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(S)-Amlodipine

CAS:103129-82-4

Ref: 4Z-A-085

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Thursday 6 Mar 2025
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(S)-Amlodipine

CAS:103129-82-4

Ref: 3B-A3608

1g66.00 €
5g139.00 €
Estimated delivery in United States, on Monday 10 Mar 2025
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(S)-Amlodipine

Controlled Product
CAS:103129-82-4

Ref: TR-A633491

1g1,511.00 €
100mg234.00 €
Estimated delivery in United States, on Monday 17 Mar 2025
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Levamlodipine

CAS:103129-82-4

Ref: 3D-FL174858

1g3,149.00 €
50mg394.00 €
100mg584.00 €
250mg1,050.00 €
500mg1,891.00 €
Estimated delivery in United States, on Friday 28 Mar 2025
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