CAS 10314-90-6

Deacetylgedunin

Description:

Deacetylgedunin is a natural compound classified as a limonoid, primarily derived from the seeds of the neem tree (Azadirachta indica). It is known for its complex molecular structure, which includes multiple rings and functional groups that contribute to its biological activity. This compound exhibits various pharmacological properties, including anti-inflammatory, anti-cancer, and anti-microbial effects, making it a subject of interest in medicinal chemistry and pharmacology. Deacetylgedunin has been studied for its potential to inhibit certain enzymes and pathways involved in disease processes, particularly in cancer research. Its mechanism of action often involves modulation of cell signaling pathways, which can lead to apoptosis in cancer cells. Additionally, the compound's solubility and stability in different solvents can influence its bioavailability and efficacy. As research continues, deacetylgedunin may offer insights into new therapeutic strategies and the development of novel pharmaceuticals. However, further studies are needed to fully understand its mechanisms and potential applications in medicine.

Formula: C₂₆H₃₂O₆

InChI: InChI=1S/C26H32O6/c1-22(2)16-12-18(28)25(5)15(23(16,3)9-7-17(22)27)6-10-24(4)19(14-8-11-30-13-14)31-21(29)20-26(24,25)32-20/h7-9,11,13,15-16,18-20,28H,6,10,12H2,1-5H3/t15-,16+,18-,19+,20-,23-,24+,25+,26-/m1/s1

InChI key: InChIKey=HCEYJYMNIQHPPK-DXTZDJJUSA-N

SMILES: C[C@]12[C@]34[C@](C)([C@@H](OC(=O)[C@]3(O4)[H])C=5C=COC5)CC[C@@]1([C@]6(C)[C@@](C[C@H]2O)(C(C)(C)C(=O)C=C6)[H])[H]

Synonyms:

• (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-1-(3-Furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-5-hydroxy-4b,7,7,10a,12a-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione
• D-Homo-24-nor-17-oxachola-1,20,22-triene-3,16-dione, 14,15:21,23-diepoxy-7-hydroxy-4,4,8-trimethyl-, (5α,7α,13α,14β,15β,17aα)-
• Oxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione, 1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-5-hydroxy-4b,7,7,10a,12a-pentamethyl-, (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-
• Gedunin, 7-deacetyl-
• 16,17-Seco-24-nor-5α,13α,14β,17α-chola-1,20,22-trien-16-oic acid, 14,15β:21,23-diepoxy-7α,17-dihydroxy-4,4,8-trimethyl-3-oxo-, 16,17-lactone

Deacetylgedunin

CAS: 10314-90-6

Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.

Formula: C₂₆H₃₂O₆

Color and Shape: Solid

Molecular weight: 440.53

Ref: TM-T31243

7-Deacetilgedunin

Controlled Product

CAS: 10314-90-6

Applications 7-Deacetilgedunin is a dervative of Gedunin (G303503), a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity. Also an extract from neem seeds and may be responsible for its antibacterial activity.
References Gao, Q. et al.: Natural. Prod. Res., 31, 1739 (2017); Lee, S. et al.: Phytomed. Int. J. Phytother. Phytopharm., 15, 533 (2008);

Formula: C₂₆H₃₂O₆

Color and Shape: Neat

Molecular weight: 440.529

Ref: TR-D288723

7-Deacetilgedunin

CAS: 10314-90-6

7-Deacetilgedunin is a naturally occurring limonoid, which is a type of organic compound derived from the Meliaceae family of plants, notably from species like Azadirachta indica (neem) and Carapa guianensis. The compound exhibits its biological activity largely through interactions with specific cellular pathways. It has been observed to modulate signal transduction pathways, potentially influencing cellular growth and apoptosis, but the exact mechanisms can vary depending on the system.

Formula: C₂₆H₃₂O₆

Purity: Min. 95%

Molecular weight: 440.50 g/mol

Ref: 3D-KAA31490