CAS 103150-33-0

7-{[(2,2,2,-TRICHLOROETHYL)OXY]CARBONYL} BACCATIN III

Description:

7-{[(2,2,2-Trichloroethyl)oxy]carbonyl}baccatin III is a synthetic derivative of baccatin III, which is a natural product derived from the yew tree, Taxus spp. This compound is characterized by the presence of a trichloroethyl group and an ester functional group, which contribute to its chemical reactivity and potential biological activity. The trichloroethyl moiety is known for its ability to enhance lipophilicity, potentially affecting the compound's pharmacokinetics and interaction with biological targets. Baccatin III itself is a precursor in the synthesis of paclitaxel, a widely used chemotherapeutic agent. The modification of baccatin III to include the trichloroethyl group may influence its antitumor properties and selectivity. As with many synthetic derivatives, the compound's stability, solubility, and biological efficacy would be of interest in research and development contexts. Safety and handling precautions are essential due to the presence of the trichloroethyl group, which may pose health risks. Overall, this compound represents a significant area of study in medicinal chemistry and drug development.

Formula: C₃₄H₃₉Cl₃O₁₃

Synonyms:

• 7-{[(2,2,2,-TRICHLOROETHYL)OXY]CARBONYL} BACCATIN III
• Carbonic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl 2,2,2-trichloroethyl ester
• 7-O-(2,2,2-Trichloroethoxycarbonyl)baccatin III

7-Troc Baccatin III

CAS: 103150-33-0

Formula: C₃₄H₃₉Cl₃O₁₃

Molecular weight: 762.04

Ref: 4Z-P-2838

7-{[(2,2,2,-Trichloroethyl)oxy]carbonyl} Baccatin III

Controlled Product

CAS: 103150-33-0

Applications 7-{[(2,2,2,-Trichloroethyl)oxy]carbonyl} Baccatin III is a precursor to Paclitaxel (P132500).
References Denis., et al.: Tetrahedr. Lett., 35, 105 (1994), Hayashi, Y., et al.; J. Med. Chem., 46, 3782 (2003),

Formula: C₃₄H₃₉Cl₃O₁₃

Color and Shape: Neat

Molecular weight: 762.02

Ref: TR-T774140