CAS 103213-34-9

gly-pro P-nitroanilide hydrochloride

Description:

Gly-Pro P-nitroanilide hydrochloride is a synthetic compound commonly used in biochemical research, particularly in studies involving proteases and enzyme activity. This substance is a peptide derivative, consisting of the amino acids glycine (Gly) and proline (Pro), linked to a p-nitroaniline moiety. The presence of the p-nitroaniline group imparts specific chromogenic properties, making it useful as a substrate in enzyme assays, where the cleavage of the peptide bond can be monitored spectrophotometrically. Gly-Pro P-nitroanilide hydrochloride is typically a white to off-white crystalline powder, soluble in water and various organic solvents, which facilitates its use in laboratory settings. Its hydrochloride form enhances its stability and solubility. As with many chemical substances, proper handling and storage are essential, as it may pose health risks if ingested or inhaled. Overall, this compound serves as a valuable tool in the study of enzymatic processes and peptide interactions in biological systems.

Formula: C₁₃H₁₇ClN₄O₄

InChI: InChI=1/C13H16N4O4.ClH/c14-8-12(18)16-7-1-2-11(16)13(19)15-9-3-5-10(6-4-9)17(20)21;/h3-6,11H,1-2,7-8,14H2,(H,15,19);1H

SMILES: C1CC(C(=O)Nc2ccc(cc2)N(=O)=O)N(C1)C(=O)CN.Cl

Synonyms:

• glycyl-N-(4-nitrophenyl)prolinamide hydrochloride
• GP-PNA
• GLY-PRO P-NITROANILIDE HYDROCHLORIDE
• Gly-Pro-pNA (hydrochloride)
• GP-pNA, Chromogenic Substrate
• L-Prolinamide, glycyl-N-(4-nitrophenyl)-, monohydrochloride
• H-Gly-Pro-pNA
• Gly-Pro-pNA.HCl
• Gly-Pro-pNA
• glycine-proline p-nitroanilide hydrochloride
• H-Gly-Pro-p-nitroanilide

H-Gly-Pro-pNA · HCl

CAS: 103213-34-9

Excellent substrate for dipeptidylpeptidase IV (DPP IV).

Formula: C₁₃H₁₆N₄O₄·HCl

Purity: > 99%

Color and Shape: Light Yellow Powder

Molecular weight: 328.76

Ref: 01-4025614

Gly-Pro-pNA hydrochloride

CAS: 103213-34-9

Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase

Formula: C₁₃H₁₇ClN₄O₄

Purity: 99.84%

Color and Shape: Solid

Molecular weight: 328.75

Ref: TM-T36583

GP-pNA, Chromogenic Substrate

CAS: 103213-34-9

Formula: C₁₄H₁₇N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 291.3025

Ref: IN-DA007HUG

Gly-Pro-pNA hydrochloride

CAS: 103213-34-9

Gly-Pro-pNA hydrochloride

Purity: ≥98%

Molecular weight: 328.75g/mol

Ref: 54-BUP11012

H-Gly-Pro-pNA•hydrochloride

CAS: 103213-34-9

H-Gly-Pro-pNA is an antidiabetic drug that inhibits the activity of dipeptidyl peptidase IV (DPP IV), a family of enzymes that catalyses the cleavage of the amino acid sequence of proline and arginine. The inhibitory effect on DPP IV by H-Gly-Pro-pNA was demonstrated using magnetic resonance spectroscopy, chromatographic assays, and electrospray ionization mass spectrometry. H-Gly-Pro-pNA also has hydrophobic properties and can interact with other drugs that are lipophilic. In vitro assays have been used to determine the inhibition activity of H-Gly-Pro-pNA against various proteins involved in diabetes mellitus, including aminopeptidases, carboxypeptidases and endopeptidases.

Formula: C₁₃H₁₆N₄O₄•HCl

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 328.75 g/mol

Ref: 3D-FG110792