CAS 103223-57-0: 6-deoxy-6-fluoronaltrexone

Description:6-Deoxy-6-fluoronaltrexone is a synthetic derivative of the opioid antagonist naltrexone, characterized by the substitution of a fluorine atom at the 6-position of the naltrexone structure. This modification alters its pharmacological properties, potentially enhancing its selectivity and potency as an opioid receptor antagonist. The presence of the fluorine atom can influence the compound's lipophilicity, metabolic stability, and overall bioavailability. Typically, such modifications aim to improve therapeutic efficacy while minimizing side effects. The compound is primarily studied in the context of opioid addiction and pain management, where it may offer advantages over traditional naltrexone. As with many fluorinated compounds, 6-deoxy-6-fluoronaltrexone may exhibit unique interactions with biological systems, making it a subject of interest in medicinal chemistry and pharmacology. Its specific applications and effects would depend on ongoing research and clinical studies, which explore its potential benefits and mechanisms of action in various therapeutic contexts.

Formula:C₂₀H₂₄FNO₃

InChI:InChI=1/C20H24FNO3/c21-13-5-6-20(24)15-9-12-3-4-14(23)17-16(12)19(20,18(13)25-17)7-8-22(15)10-11-1-2-11/h3-4,11,13,15,18,23-24H,1-2,5-10H2/t13-,15+,18-,19+,20?/m1/s1

Synonyms:
17-Cyclopropylmethyl-3,14-dihydroxy-4,5-epoxy-6-fluoromorphinan
6-Desoxy-6-fluoronaltrexone
Cyclofoxy
Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-fluoro-, (5alpha,6beta)-
(5Beta,6Beta,9Alpha)-17-(Cyclopropylmethyl)-6-Fluoro-4,5-Epoxymorphinan-3,14-Diol
6-Deoxy-6-fluoronaltrexone