SIM010603, identified by its CAS number 1032265-67-0, is a chemical compound that falls under the category of small molecules. While specific characteristics such as its molecular formula, structure, and physical properties may not be widely documented, compounds with similar identifiers often exhibit unique biological activities or applications in fields such as medicinal chemistry or materials science. Typically, such substances may possess specific functional groups that contribute to their reactivity and interactions with biological systems. The compound may also have implications in drug development, potentially acting as a lead compound for further synthesis and optimization. For precise details regarding its solubility, stability, and specific applications, consulting specialized chemical databases or scientific literature is recommended, as these resources provide comprehensive insights into the compound's behavior and potential uses in various scientific domains.

SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis.

SIM010603

1032265-67-0: SIM010603, identified by its CAS number 1032265-67-0, is a chemical compound that falls under the category of small molecules. While specific characteristics such as its molecular formula, structure, and physical properties may not be widely documented, compounds with similar identifiers often exhibit unique biological activities or applications in fields such as medicinal chemistry or materials science. Typically, such substances may possess specific functional groups that contribute to their reactivity and interactions with biological systems. The compound may also have implications in drug development, potentially acting as a lead compound for further synthesis and optimization. For precise details regarding its solubility, stability, and specific applications, consulting specialized chemical databases or scientific literature is recommended, as these resources provide comprehensive insights into the compound's behavior and potential uses in various scientific domains.

<p>SIM010603, an oral RTK inhibitor, targets Kit, VEGFR-2, PDGFR-β, RET, FLT3 (IC50: 5.0-68.1 nmol/l), inhibits cell proliferation and angiogenesis.</p>

CAS 1032265-67-0

SIM010603

SIM010603

Ref: TM-T71576