12(S)-HPEPE, or 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid, is a bioactive lipid derived from the metabolism of arachidonic acid. It is classified as a hydroxy fatty acid and is known for its role in various physiological processes, particularly in inflammation and cell signaling. This compound is characterized by the presence of a hydroxyl group at the 12th carbon position of its eicosatetraenoic backbone, which contributes to its biological activity. 12(S)-HPEPE is involved in the synthesis of specialized pro-resolving mediators, which are crucial for resolving inflammation and promoting tissue repair. Its effects are mediated through specific receptors and pathways, influencing processes such as vascular function and immune response. The compound is typically studied in the context of cardiovascular health, neuroprotection, and inflammatory diseases. As a relatively specific lipid mediator, it has garnered interest for its potential therapeutic applications in managing conditions associated with chronic inflammation.

12(S)-
HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 12-
lipoxygenase on eicosapentaenoic acid. Although the biological activities of 12(S)-
HpEPE have not been well characterized, it is expected to behave similarly to 12(S)-
HpETE (Catalog No.
44570
).

12(S)-HPEPE

103239-14-1: 12(S)-HPEPE, or 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid, is a bioactive lipid derived from the metabolism of arachidonic acid. It is classified as a hydroxy fatty acid and is known for its role in various physiological processes, particularly in inflammation and cell signaling. This compound is characterized by the presence of a hydroxyl group at the 12th carbon position of its eicosatetraenoic backbone, which contributes to its biological activity. 12(S)-HPEPE is involved in the synthesis of specialized pro-resolving mediators, which are crucial for resolving inflammation and promoting tissue repair. Its effects are mediated through specific receptors and pathways, influencing processes such as vascular function and immune response. The compound is typically studied in the context of cardiovascular health, neuroprotection, and inflammatory diseases. As a relatively specific lipid mediator, it has garnered interest for its potential therapeutic applications in managing conditions associated with chronic inflammation.

<p>12(S)-HpEPE, a fatty acid created by 12-lipoxygenase on EPA, has unclear biological activities but may resemble 12(S)-HpETE.</p>

CAS 103239-14-1

12(S)-HPEPE

12(S)-HpEPE

Ref: TM-T37968

12(S)-hydroperoxy-5(Z),8(Z),10(E),14(Z),17(Z)-eicosapentaenoic acid

Ref: 48-12-2051