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CAS 103285-22-9

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5'-O-(4,4'-DIMETHOXYTRITYL)-2'-O-METHYLURIDINE

Description:
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine is a modified nucleoside that plays a significant role in nucleic acid chemistry, particularly in the synthesis of RNA oligonucleotides. This compound features a uridine base, which is a nucleoside composed of a ribose sugar and a uracil base, with specific modifications that enhance its stability and solubility. The presence of the 4,4'-dimethoxytrityl (DMT) group at the 5' position serves as a protective group, facilitating the selective synthesis of oligonucleotides by preventing unwanted reactions during the coupling process. The 2'-O-methyl modification contributes to increased resistance to nucleases, thereby enhancing the stability of the RNA strand in biological environments. This compound is typically used in the field of molecular biology for the synthesis of RNA molecules, including those used in therapeutic applications and research. Its unique structural features make it a valuable tool in the development of RNA-based technologies.
Formula:C31H32N2O8
Synonyms:
  • Dmt-2'-O-Methyluridine
  • 5'-O-(Dimethoxytrityl)-2'-O-Methyluridine
  • 5'-O-DMT-2'-O-methyl-D-uridine
  • 2'-O-Methyl-5'-O-DMT-Uridine
  • 5'-O-DMT-2'-O-Methyl-Uridine
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