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CAS 103336-05-6

:

ditekiren

Description:
Ditekiren, with the CAS number 103336-05-6, is a chemical compound that belongs to the class of selective bradykinin B2 receptor antagonists. It is primarily investigated for its potential therapeutic applications, particularly in the treatment of conditions associated with excessive bradykinin activity, such as certain cardiovascular and inflammatory disorders. The compound exhibits a specific mechanism of action by inhibiting the bradykinin B2 receptor, which plays a crucial role in mediating pain, inflammation, and vasodilation. Ditekiren is characterized by its unique molecular structure, which contributes to its binding affinity and selectivity for the target receptor. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are essential for determining its efficacy and safety profile in clinical settings. As with many pharmacological agents, ongoing research is focused on understanding its full therapeutic potential, side effects, and interactions with other medications.
Formula:C50H75N9O8
InChI:InChI=1/C50H75N9O8/c1-11-33(6)43(47(64)53-29-35-20-15-16-22-52-35)57-44(61)37(32(4)5)27-42(60)38(24-31(2)3)55-46(63)41(26-36-28-51-30-54-36)58(10)48(65)39(25-34-18-13-12-14-19-34)56-45(62)40-21-17-23-59(40)49(66)67-50(7,8)9/h12-16,18-20,22,28,30-33,37-43,60H,11,17,21,23-27,29H2,1-10H3,(H,51,54)(H,53,64)(H,55,63)(H,56,62)(H,57,61)/t33-,37-,38-,39-,40-,41-,42-,43-/m0/s1
SMILES:CC[C@H](C)[C@@H](C(=NCc1ccccn1)O)N=C([C@@H](C[C@@H]([C@H](CC(C)C)N=C([C@H](Cc1cnc[nH]1)N(C)C(=O)[C@H](Cc1ccccc1)N=C([C@@H]1CCCN1C(=O)OC(C)(C)C)O)O)O)C(C)C)O
Synonyms:
  • Ditekiren [USAN:INN]
  • Ditekirene
  • Ditekirene [INN-French]
  • Ditekirenum
  • Ditekirenum [INN-Latin]
  • Ditiquireno
  • Ditiquireno [INN-Spanish]
  • L-Histidinamide, 1-((1,1-dimethylethoxy)carbonyl)-L-prolyl-L-phenylalanyl-N-(2-hydroxy-5-methyl-1-(2-methylpropyl)-4-(((2-methyl-1-(((2-pyridinylmethyl)amino)carbonyl)butyl)amino)carbonyl)hexyl)-N(sup alpha)-methyl-, (1S-(1R*,2R*,4R*(1R*,2R*)))-
  • tert-Butyl (2S)-2-(((alphaS)-alpha-(((1S)-1-(((1S,2S,4S)-2-hydroxy-1-isobutyl-5-methyl-4-(((1S,2S)-2-methyl-1-((2-pyridylmethyl)carbamoyl)butyl)carbamoyl)hexyl)carbamoyl)-2-imidazol-4-ylethyl)methylcarbamoyl)phenethyl)carbamoyl)-1-pyrrolidinecarboxylate
  • L-Histidinamide, 1-((1,1-dimethylethoxy)carbonyl)-L-prolyl-L-phenylalanyl-N-(2-hydroxy-5-methyl-1-(2-methylpropyl)-4-(((2-methyl-1-(((2-pyridinylemthyl)amino)carbonyl)butyl)amino)carbonyl)hexyl)-Nalpha-methyl-, (1S-(1R*,2R*,4R*(1R*,2R*)))-
  • See more synonyms
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Found 2 products.
  • Ditekiren
    Targetmol
    + Info

    Ditekiren

    CAS:
    <p>Ditekiren is a renin inhibitor with orally active.</p>
    Formula:C50H75N9O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:930.19

    Ref: TM-T25345

  • Ditekiren
    TRC
    + Info

    Ditekiren

    Controlled Product
    CAS:
    <p>Applications Ditekiren, is a potent and specific Renin inhibitor pseudohexapeptide with high metabolic stability.<br>References Thaisrivongs S., et a;.: J. Med. Chem, 29, 10, 2088 (1986); Adedoyin, A., et al.: Drug Metabolism and Disposition, 21, 184 (1993);<br></p>
    Formula:C50H75N9O8
    Color and Shape:Neat
    Molecular weight:930.186

    Ref: TR-D493685

    25mg
    40,547.00€