CAS 1033735-94-2

GNE-493

Description:

GNE-493, identified by its CAS number 1033735-94-2, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its role as a selective inhibitor of certain kinases. This compound is characterized by its ability to modulate specific signaling pathways, making it a subject of interest in cancer research and other therapeutic areas. GNE-493 exhibits a unique molecular structure that contributes to its biological activity, often leading to the inhibition of cell proliferation in various cancer cell lines. Its pharmacological profile suggests potential applications in targeted therapies, although further studies are necessary to fully elucidate its efficacy and safety in clinical settings. Additionally, the compound's solubility, stability, and interaction with biological systems are critical factors that influence its development as a therapeutic agent. As research progresses, GNE-493 may provide insights into novel treatment strategies for diseases characterized by dysregulated kinase activity.

Formula: C₁₇H₂₀N₆O₂S

InChI: InChI=1S/C17H20N6O2S/c1-17(2,24)12-7-11-13(26-12)15(23-3-5-25-6-4-23)22-14(21-11)10-8-19-16(18)20-9-10/h7-9,24H,3-6H2,1-2H3,(H2,18,19,20)

SMILES: CC(C)(c1cc2c(c(nc(c3c[nH]c(=N)nc3)n2)N2CCOCC2)s1)O

Synonyms:

• :Thieno[3,2-d]pyrimidine-6-methanol, 2-(2-amino-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)-

GNE-493

CAS: 1033735-94-2

Formula: C₁₇H₂₀N₆O₂S

Purity: 97%

Molecular weight: 372.4447

Ref: IN-DA008TGJ

2-(2-(2-Aminopyrimidin-5-Yl)-4-Morpholinothieno[3,2-D]Pyrimidin-6-Yl)Propan-2-Ol

CAS: 1033735-94-2

2-(2-(2-Aminopyrimidin-5-Yl)-4-Morpholinothieno[3,2-D]Pyrimidin-6-Yl)Propan-2-Ol

Purity: 99%

Molecular weight: 372.44g/mol

Ref: 54-OR1023041

GNE-493

CAS: 1033735-94-2

GNE-493

Purity: ≥95%

Molecular weight: 372.44g/mol

Ref: 54-BUP03044

GNE-493

CAS: 1033735-94-2

GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for

Formula: C₁₇H₂₀N₆O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 372.44

Ref: TM-T7166

GNE-493

CAS: 1033735-94-2

Ref: 7W-GW9776

GNE-493

CAS: 1033735-94-2

GNE-493 is a synthetic compound that is currently under development for its potential as a cancer biomarker and therapeutic agent. GNE-493 binds to the pro-apoptotic protein Bax, which is located in the mitochondrial membrane. This binding induces Bax oligomerization and release of cytochrome C from the mitochondria into the cytosol, where it activates caspases and triggers apoptosis. GNE-493 has been shown to induce cell death in several types of cancer cells (e.g., miapaca-2 cells) and potent antitumor activity in mice bearing human colon carcinoma xenografts. GNE-493 also inhibits tumor growth by inhibiting cyclin D1 expression and decreasing the mitochondrial membrane potential, leading to cell cycle arrest at the G0/G1 checkpoint.

Formula: C₁₇H₂₀N₆O₂S

Purity: Min. 95%

Molecular weight: 372.44 g/mol

Ref: 3D-IRB73594