CAS 1033805-22-9

4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester

Description:

The chemical substance known as 4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester, with CAS number 1033805-22-9, is a complex organic compound characterized by its multi-functional structure. It features a pyrimidine ring, which is a six-membered aromatic heterocycle containing nitrogen atoms, and an amino acid moiety, specifically L-phenylalanine, which contributes to its biological activity. The presence of a trifluoroethoxy group and a chloro-substituted phenyl ring indicates potential for significant interactions in biological systems, possibly influencing its pharmacological properties. Additionally, the compound contains a pyrazole moiety, which is known for its diverse biological activities, including anti-inflammatory and anti-cancer effects. The ethyl ester functional group suggests that the compound may exhibit enhanced lipophilicity, potentially affecting its absorption and distribution in biological systems. Overall, this compound's intricate structure suggests it may be of interest in medicinal chemistry and drug development.

Formula: C₂₇H₂₆ClF₃N₆O₃

InChI: InChI=1S/C27H26ClF3N6O3/c1-3-39-25(38)20(32)12-16-4-6-17(7-5-16)21-14-23(35-26(33)34-21)40-24(27(29,30)31)19-9-8-18(28)13-22(19)37-11-10-15(2)36-37/h4-11,13-14,20,24H,3,12,32H2,1-2H3,(H2,33,34,35)/t20-,24+/m0/s1

InChI key: InChIKey=MDSQOJYHHZBZKA-GBXCKJPGSA-N

SMILES: [C@H](OC=1C=C(N=C(N)N1)C2=CC=C(C[C@@H](C(OCC)=O)N)C=C2)(C(F)(F)F)C3=C(C=C(Cl)C=C3)N4C=CC(C)=N4

Synonyms:

• (2S)-2-Amino-3-[4-[2-amino-6-[[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethyl]oxy]pyrimidin-4-yl]phenyl]propionic acid ethyl ester
• 4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-<span class="text-smallcaps">L</span>-phenylalanine ethyl ester
• <span class="text-smallcaps">L</span>-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester
• Lx 1032
• Lx 1606
• Lx1032
• Telotristat ethyl
• Xermelo
• 4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester
• L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester

LX-1606 Hippurate

CAS: 1033805-22-9

Formula: C₂₇H₂₆ClF₃N₆O₃

Purity: %

Color and Shape: Solid

Molecular weight: 574.9819

Ref: IN-DA008THI

Telotristat ethyl

CAS: 1033805-22-9

Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

Formula: C₂₇H₂₆ClF₃N₆O₃

Purity: 98% - 99.89%

Color and Shape: White Solid

Molecular weight: 574.98

Ref: TM-T11897

Telotristat Ethyl

CAS: 1033805-22-9

Telotristat Ethyl

Purity: 98%

Molecular weight: 574.98g/mol

Ref: 54-PC108553

Telotristat ethyl

CAS: 1033805-22-9

Telotristat ethyl

Purity: ≥95%

Molecular weight: 574.98g/mol

Ref: 54-BUP09452

Ethyl Telotristat

CAS: 1033805-22-9

Formula: C₂₇H₂₆ClF₃N₆O₃

Molecular weight: 574.99

Ref: 4Z-T-135003

Telotristat Ethyl

Controlled Product

CAS: 1033805-22-9

Applications Telotristat Ethyl can be used in biological study of serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation.
References Welford, R. W. D., et al.: Scientific Reports, 6, 30059 (2016)

Formula: C₂₇H₂₆ClF₃N₆O₃

Color and Shape: Neat

Molecular weight: 574.98

Ref: TR-T017098

(S)-Ethyl2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol -1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate

CAS: 1033805-22-9

Telotristat ethyl is a pharmacological treatment for carcinoid syndrome, which is caused by the release of serotonin from enterochromaffin cells in the intestine. Telotristat ethyl inhibits serotonin release by reversibly inhibiting serotonin release from enterochromaffin cells and other cell types that express 5-HT4 receptors. This drug has no effect on the release of histamine or acetylcholine and does not cross the blood-brain barrier. Telotristat ethyl has shown long-term efficacy in people with carcinoid syndrome and minimal toxicity profiles. The most common side effects are diarrhoea, nausea, vomiting, abdominal pain, headache, and dizziness.

Formula: C₂₇H₂₆ClF₃N₆O₃

Purity: Min. 95%

Molecular weight: 574.98 g/mol

Ref: 3D-FE157240

Ethyl Telotristat

CAS: 1033805-22-9

Formula: C₂₇H₂₆ClF₃N₆O₃

Molecular weight: 574.99

Ref: ST-EA-CP-T258000