CAS 103408-45-3

Pyrimido[1,2-a]purin-10(3H)-one

Description:

Pyrimido[1,2-a]purin-10(3H)-one, with the CAS number 103408-45-3, is a heterocyclic compound that belongs to the purine family. This substance features a fused pyrimidine and purine ring system, which contributes to its biological activity. It typically exhibits a planar structure, allowing for effective interactions with biological macromolecules, such as nucleic acids and proteins. The compound is often studied for its potential pharmacological properties, including antiviral and anticancer activities, due to its ability to interfere with nucleic acid synthesis. Its solubility and stability can vary depending on the solvent and environmental conditions, which are important factors for its application in medicinal chemistry. Additionally, the presence of functional groups in its structure may influence its reactivity and binding affinity to target molecules. Overall, Pyrimido[1,2-a]purin-10(3H)-one represents a significant compound in the field of drug discovery and development, warranting further investigation into its therapeutic potential.

Formula: C₈H₅N₅O

InChI: InChI=1S/C8H5N5O/c14-7-5-6(11-4-10-5)12-8-9-2-1-3-13(7)8/h1-4H,(H,10,11)

InChI key: InChIKey=ZREGNVKUSNORFO-UHFFFAOYSA-N

SMILES: O=C1C2=C(N=C3N1C=CC=N3)N=CN2

Synonyms:

• Guanine-malondialdehyde adduct
• Pyrimido[1,2-a]purin-10(3H)-one
• Pyrimido[1,2-a]purin-10(1H)-one
• Pyrimido(1,2-a)purin-10(1H)-one

Pyrimido[1,2-a]purin-10(1H)-one

Controlled Product

CAS: 103408-45-3

Applications M1G is a secondary DNA damage product arising from primary reactive oxygen species (ROS) damage to membrane lipids or deoxyribose. It is a guanine adduct formed by reaction of malondialdehyde with DNA.
References Ham, A., et al.: Chem. Res. Toxicol., 13, 1243 (2000), Sharma, R., et al.: Clin. Cancer Res., 7, 1452 (2001), Jeong, Y., et al.: Chem. Res. Toxicol., 18, 51 (2005),

Formula: C₈H₅N₅O

Color and Shape: Neat

Molecular weight: 187.16

Ref: TR-P997400

Pyrimido[1,2-a]purin-10(1H)-one

CAS: 103408-45-3

Pyrimido[1,2-a]purin-10(1H)-one is a cytotoxic drug used in the treatment of various cancers. It is an analog of purine nucleoside and has been shown to inhibit mitochondrial functions and nuclear DNA synthesis, as well as to induce malondialdehyde production. Pyrimido[1,2-a]purin-10(1H)-one also inhibits protein synthesis by methyltransferase inhibition. The detection sensitivity of pyrimido[1,2-a]purin-10(1H)-one has been demonstrated using titration calorimetry on sephadex g-100 columns. This compound is not active against E. coli K12 but is active against other bacteria including Staphylococcus aureus isolates that are resistant to methicillin.

Formula: C₈H₅N₅O

Purity: Min. 95%

Molecular weight: 187.16 g/mol

Ref: 3D-DEA40845