CAS 103412-42-6

D-arg(hyp3,thi5,8,D-phe7)-bradykinin

Description:

D-arg(hyp3,thi5,8,D-phe7)-bradykinin, also known by its CAS number 103412-42-6, is a synthetic analog of the naturally occurring peptide bradykinin, which is involved in various physiological processes, including vasodilation and inflammation. This compound features several modifications that enhance its stability and biological activity compared to the native bradykinin. The presence of D-arginine and the substitutions at positions 3, 5, 7, and 8 contribute to its resistance to enzymatic degradation, making it a valuable tool in pharmacological research. The peptide is typically characterized by its ability to interact with bradykinin receptors, influencing cardiovascular and pain pathways. Its structure includes a sequence of amino acids that are crucial for receptor binding and activation. Due to its specific modifications, D-arg(hyp3,thi5,8,D-phe7)-bradykinin is often studied for its potential therapeutic applications, particularly in conditions related to cardiovascular health and pain management.

Formula: C₅₆H₈₃N₁₉O₁₃S₂

InChI: InChI=1/C56H83N19O13S2/c57-35(13-4-17-66-53(60)61)45(80)71-38(14-5-18-67-54(62)63)50(85)74-20-6-15-42(74)44(79)34(16-19-68-55(64)65)56(52(87)88,43(78)28-70-47(82)39-24-31(77)27-69-39)75(49(84)37(59)26-33-12-8-22-90-33)51(86)40(23-30-9-2-1-3-10-30)72-48(83)41(29-76)73-46(81)36(58)25-32-11-7-21-89-32/h1-3,7-12,21-22,31,34-42,69,76-77H,4-6,13-20,23-29,57-59H2,(H,70,82)(H,71,80)(H,72,83)(H,73,81)(H,87,88)(H4,60,61,66)(H4,62,63,67)(H4,64,65,68)/t31-,34?,35-,36+,37+,38+,39+,40-,41+,42+,56-/m1/s1

Synonyms:

• B 4881
• L-Arginine, N2-(N-(N-(N-(N-(N-(1-(1-(N2-D-arginyl-L-arginyl)-L-prolyl)-trans-4-hydroxy-L-prolyl)glycyl)-3-(2-thienyl)-L-alanyl)-L-seryl)-D-phenylalanyl)-3-(2-thienyl)-L-alanyl)-
• Npc 349
• B-4162
• (D-Arg0,Hyp3,Beta-(2-Thienyl)-Ala5,8,D-Phe7)-Bradykinin
• Bradykinin, arg-hyp(3)-gly-(2-thi-ala)(5)-phe(7)-(2-thi-ala)(8)-
• Arg-3-hyp-5-(2-thi-ala)-7-phe-8-(2-thi-ala)-bradykinin
• B4881
• B 6572
• B-6572
• (Arg(0)-hyp(3)-thi(5)-phe(7)-thi(8))bradykinin
• Arg(0)-(hyp(3)-thi(5,8)-D-phe(7))-BK
• Bradykinin, arginyl-hydroxyproly(3)-(2-thienylalanyl)(5)-phenylalanyl(7)-(2-thienylalanine)(8)-
• Arginyl-arginyl-prolyl-hydroxyprolyl-glycl-(2-thienyl)alanyl-seryl-phenylalanyl-(2-thienyl)alanyl-arginine
• B-4881
• (2R)-3-{[(2S)-1-{(2S)-2-({(2R)-2-amino-5-[(diaminomethylidene)amino]pentanoyl}amino)-5-[(diaminomethylidene)amino]pentanoyl}pyrrolidin-2-yl]carbonyl}-2-{[(2S)-2-amino-3-(thiophen-2-yl)propanoyl][(2R)-2-{[(2S)-2-{[(2S)-2-amino-3-(thiophen-2-yl)propanoyl]amino}-3-hydroxypropanoyl]amino}-3-phenylpropanoyl]amino}-5-[(diaminomethylidene)amino]-2-[({[(2S,4R)-4-hydroxypyrrolidin-2-yl]carbonyl}amino)acetyl]pentanoic acid (non-preferred name)
• D-Arg-(hyp(3),thi(5,8),D-phe(7))bradykinin
• B 4162
• Bradykinin, D-arg(0)-hyp(3)-D-phe(7)-thi(5,8)

D-Arginyl-[Hyp3,Thi5,8,D-Phe7]-Bradykinin

CAS: 103412-42-6

D-Arginyl-[Hyp3,Thi5,8,D-Phe7]-Bradykinin is a peptide that is used as a pharmacological research tool. It has been shown to activate certain ion channels and bind to certain receptors. This compound has also been shown to inhibit the binding of some ligands to their receptors. D-Arginyl-[Hyp3,Thi5,8,D-Phe7]-Bradykinin has been purified from the venom of a scorpion species Daboia russelii. This peptide is a potent inhibitor for atrial natriuretic peptide receptor B (NPRB).

Formula: C₅₆H₈₃N₁₉O₁₃S₂

Purity: Min. 95%

Molecular weight: 1,294.5 g/mol

Ref: 3D-PBK-4202-V