CAS 1034148-04-3

2,2,2-Trifluoro-N-[(1S,2R)-2-[[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy]-2-(3-methoxyphenyl)-1-methylethyl]acetamide

Description:

2,2,2-Trifluoro-N-[(1S,2R)-2-[[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy]-2-(3-methoxyphenyl)-1-methylethyl]acetamide is a complex organic compound characterized by its trifluoromethyl group, which enhances its lipophilicity and biological activity. The presence of multiple aromatic rings, including a fluorophenyl and a methoxyphenyl group, contributes to its potential as a pharmacological agent, likely influencing its interaction with biological targets. The compound features a chiral center, indicated by the (1S,2R) configuration, which may affect its pharmacodynamics and pharmacokinetics. Its acetamide functional group suggests potential for hydrogen bonding, which can be crucial for its solubility and reactivity. The trifluoromethyl group is known to impart unique electronic properties, making the compound of interest in medicinal chemistry. Overall, this substance may exhibit significant biological activity, warranting further investigation for therapeutic applications, particularly in the context of drug development.

Formula: C₂₅H₂₁F₄N₃O₃

InChI: InChI=1S/C25H21F4N3O3/c1-15(31-24(33)25(27,28)29)23(16-4-3-5-20(12-16)34-2)35-21-10-11-22-17(13-21)14-30-32(22)19-8-6-18(26)7-9-19/h3-15,23H,1-2H3,(H,31,33)/t15-,23-/m0/s1

InChI key: InChIKey=FCNQMDSJHADDFT-WNSKOXEYSA-N

SMILES: O([C@@H]([C@@H](NC(C(F)(F)F)=O)C)C1=CC(OC)=CC=C1)C=2C=C3C(N(N=C3)C4=CC=C(F)C=C4)=CC2

Synonyms:

• AZD 5423
• 2,2,2-Trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide
• Acetamide, 2,2,2-trifluoro-N-[(1S,2R)-2-[[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy]-2-(3-methoxyphenyl)-1-methylethyl]-
• 2,2,2-Trifluoro-N-[(1S,2R)-2-[[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy]-2-(3-methoxyphenyl)-1-methylethyl]acetamide
• AZD5423

AZD5423

CAS: 1034148-04-3

AZD5423: Inhaled, potent GR modulator, non-steroidal, curbs allergy asthma symptoms.

Formula: C₂₅H₂₁F₄N₃O₃

Purity: 98.76%

Color and Shape: Solid

Molecular weight: 487.45

Ref: TM-T14377

AZD5423

CAS: 1034148-04-3

AZD5423

Purity: ≥98%

Molecular weight: 487.45g/mol

Ref: 54-BUP09832

AZD5423

CAS: 1034148-04-3

AZD5423 is a fatty acid that has inhibitory properties on the cells in the colon. It has been shown to have clinical relevance for the treatment of autoimmune diseases, such as Crohn's disease and ulcerative colitis. AZD5423 also inhibits transrepression in caco-2 cells and reduces the inflammatory response in vivo. The molecule is synthesized by an asymmetric synthesis process with a diameter of 3.7 nm and potent inhibition against particle size of 2.5 nm. Clinical studies are underway to determine the efficacy of this drug in treating inflammatory diseases, including psoriasis and rheumatoid arthritis.

Formula: C₂₅H₂₁F₄N₃O₃

Purity: Min. 95%

Molecular weight: 487.45 g/mol

Ref: 3D-JRB14804