CAS 1034148-04-3: 2,2,2-Trifluoro-N-[(1S,2R)-2-[[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy]-2-(3-methoxyphenyl)-1-methylethyl]acetamide

Description:2,2,2-Trifluoro-N-[(1S,2R)-2-[[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy]-2-(3-methoxyphenyl)-1-methylethyl]acetamide is a complex organic compound characterized by its trifluoromethyl group, which enhances its lipophilicity and biological activity. The presence of multiple aromatic rings, including a fluorophenyl and a methoxyphenyl group, contributes to its potential as a pharmacological agent, likely influencing its interaction with biological targets. The compound features a chiral center, indicated by the (1S,2R) configuration, which may affect its pharmacodynamics and pharmacokinetics. Its acetamide functional group suggests potential for hydrogen bonding, which can be crucial for its solubility and reactivity. The trifluoromethyl group is known to impart unique electronic properties, making the compound of interest in medicinal chemistry. Overall, this substance may exhibit significant biological activity, warranting further investigation for therapeutic applications, particularly in the context of drug development.

Formula:C₂₅H₂₁F₄N₃O₃

InChI:InChI=1S/C25H21F4N3O3/c1-15(31-24(33)25(27,28)29)23(16-4-3-5-20(12-16)34-2)35-21-10-11-22-17(13-21)14-30-32(22)19-8-6-18(26)7-9-19/h3-15,23H,1-2H3,(H,31,33)/t15-,23-/m0/s1

InChI key:InChIKey=FCNQMDSJHADDFT-WNSKOXEYSA-N

SMILES:O=C(NC(C)C(OC=1C=CC2=C(C=NN2C3=CC=C(F)C=C3)C1)C=4C=CC=C(OC)C4)C(F)(F)F

Synonyms:
AZD 5423
2,2,2-Trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide
Acetamide, 2,2,2-trifluoro-N-[(1S,2R)-2-[[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy]-2-(3-methoxyphenyl)-1-methylethyl]-
2,2,2-Trifluoro-N-[(1S,2R)-2-[[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy]-2-(3-methoxyphenyl)-1-methylethyl]acetamide
AZD5423