CAS 103419-09-6

1-fluoroestradiol

Description:

1-Fluoroestradiol is a synthetic derivative of estradiol, which is a primary female sex hormone. This compound is characterized by the presence of a fluorine atom at the 1-position of the estradiol structure, which can influence its biological activity and receptor binding properties. As a fluorinated analog, 1-fluoroestradiol may exhibit altered pharmacokinetics and enhanced metabolic stability compared to its non-fluorinated counterparts. It is primarily studied for its potential applications in hormone replacement therapy and cancer treatment, particularly in estrogen receptor-positive cancers. The introduction of the fluorine atom can enhance lipophilicity, potentially affecting its distribution and accumulation in tissues. Additionally, 1-fluoroestradiol can be utilized in research settings to investigate estrogen receptor interactions and signaling pathways. Safety and handling precautions are essential when working with this compound, as with any synthetic hormone analog, due to its biological activity and potential effects on endocrine systems.

Formula: C₁₈H₂₃FO₂

InChI: InChI=1/C18H23FO2/c1-18-7-6-13-12(14(18)4-5-16(18)21)3-2-10-8-11(20)9-15(19)17(10)13/h8-9,12-14,16,20-21H,2-7H2,1H3/t12-,13+,14+,16+,18+/m1/s1

Synonyms:

• Estra-1,3,5(10)-triene-3,17-diol, 1-fluoro-, (17beta)-
• (17Beta)-1-Fluoroestra-1,3,5(10)-Triene-3,17-Diol
• 1-Fluoroestradiol