CAS 103420-77-5

Devazepide

Description:

Devazepide, with the CAS number 103420-77-5, is a chemical compound that acts as a selective antagonist of the cholecystokinin (CCK) receptor. It is primarily studied for its potential therapeutic applications in gastrointestinal disorders and obesity management. The compound is characterized by its ability to inhibit the action of CCK, a hormone that plays a significant role in digestion and appetite regulation. Devazepide is typically administered in research settings to explore its effects on food intake and gastric motility. Its molecular structure includes specific functional groups that contribute to its receptor-binding properties. The compound is usually presented in a solid form and is soluble in organic solvents, which facilitates its use in various experimental protocols. Safety and handling precautions are essential when working with Devazepide, as with any chemical substance, to mitigate potential health risks. Overall, Devazepide represents a valuable tool in pharmacological research aimed at understanding and manipulating appetite and digestive processes.

Formula: C₂₅H₂₀N₄O₂

InChI: InChI=1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1

InChI key: InChIKey=NFHRQQKPEBFUJK-HSZRJFAPSA-N

SMILES: N(C(=O)C1=CC=2C(N1)=CC=CC2)[C@H]3N=C(C=4C(N(C)C3=O)=CC=CC4)C5=CC=CC=C5

Synonyms:

• (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)indole-2-carboxamide
• 1H-1,4-Benzodiazepine, 1H-indole-2-carboxamide deriv.
• 1H-Indole-2-carboxamide, N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-, (S)-
• 1H-Indole-2-carboxamide, N-[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-
• 3(S)-(-)-1,3-Dihydro-3-(2-indolecarbonylamino)-1-methyl-5-phenyl-2H-(1,4)benzodiazepin-2-one
• Brn 5156082
• Devacade
• Devazepida
• Devazepida [INN-Spanish]
• Devazepide [USAN:INN]
• Devazepidum
• Devazepidum [INN-Latin]
• L 364718
• Mk-329
• N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-1H-indole-2-carboxamide
• N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
• N-[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
• Unii-Je6P7Qy7Nh
• Zinc 01847292

Devazepide

CAS: 103420-77-5

Formula: C₂₅H₂₀N₄O₂

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 408.45

Ref: 7W-GP3478

Devazepide

CAS: 103420-77-5

Devazepide: oral nonpeptide CCK receptor antagonist; IC50s - 81 pM (rat pancreas), 45 pM (bovine gallbladder), 245 nM (guinea pig brain).

Formula: C₂₅H₂₀N₄O₂

Color and Shape: Solid

Molecular weight: 408.45

Ref: TM-T15101

Devazepide

CAS: 103420-77-5

Purity: 98%(HPLC)

Molecular weight: 408.4609985

Ref: 10-F866363

Devazepide

Controlled Product

CAS: 103420-77-5

Formula: C₂₅H₂₀N₄O₂

Color and Shape: Neat

Molecular weight: 408.452

Ref: TR-D535518

Devazepide

Controlled Product

CAS: 103420-77-5

Devazepide is a peptide that blocks the action of cholecystokinin, which is involved in the regulation of food intake and pancreatic function. Devazepide has been shown to inhibit the binding of cholecystokinin to its receptor in vitro, and antagonizes cholecystokinin-induced cytosolic Ca2+ increase, pancreatic secretion, and cck-a release. Devazepide has also been shown to be an antagonist of estrogen-benzoate receptors. This drug has been used as an experimental model for studying brain functions and physiological effects. Low potency may be due to its low affinity for the receptor or its inefficient absorption into the bloodstream.

Formula: C₂₅H₂₀N₄O₂

Purity: Min. 95%

Molecular weight: 408.45 g/mol

Ref: 3D-DEA42077