CAS 103475-41-8

tepoxalin

Description:

Tepoxalin is a non-steroidal anti-inflammatory drug (NSAID) primarily used in veterinary medicine, particularly for the treatment of pain and inflammation in dogs and cats. It functions by inhibiting the activity of cyclooxygenase enzymes (COX-1 and COX-2), which play a crucial role in the synthesis of prostaglandins, compounds that mediate inflammation and pain. Tepoxalin is characterized by its rapid absorption and metabolism, leading to a relatively quick onset of action. The substance is typically administered orally and is available in various formulations, including tablets. Tepoxalin's safety profile is generally favorable, but like all NSAIDs, it may pose risks of gastrointestinal, renal, or hepatic side effects, particularly with prolonged use or in animals with pre-existing conditions. Its chemical structure includes a unique combination of functional groups that contribute to its pharmacological properties. As with any medication, it is essential to follow veterinary guidance regarding dosage and administration to ensure the well-being of the animal.

Formula: C₂₀H₂₀ClN₃O₃

InChI: InChI=1/C20H20ClN3O3/c1-23(26)20(25)12-7-16-13-19(14-3-5-15(21)6-4-14)24(22-16)17-8-10-18(27-2)11-9-17/h3-6,8-11,13,26H,7,12H2,1-2H3

InChI key: InChIKey=XYKWNRUXCOIMFZ-UHFFFAOYSA-N

SMILES: C(CC(N(C)O)=O)C1=NN(C(=C1)C2=CC=C(Cl)C=C2)C3=CC=C(OC)C=C3

Synonyms:

• 1H-Pyrazole-3-propanamide, 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-
• 3-(5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl)-N-hydroxy-N-methylpropanamide
• 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
• 5-(4-Chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide
• 5-(p-Chlorophenyl)-1-(p-methoxyphenyl)-N-methylpyrazole-3-propionohydroxamic acid
• Orf 20485
• Rwj 20485
• Tepoxalin [USAN:INN]
• Tepoxalina
• Tepoxalina [Spanish]
• Tepoxaline
• Tepoxaline [French]
• Tepoxalinum
• Tepoxalinum [Latin]
• Unii-Tz4Ox61974
• Zubrin
• Tepoxalin
• Tepoxalin
• 3-[1-(4-Methoxyphenyl)-5-(4-chlorophenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
• epoxalin

Tepoxalin

CAS: 103475-41-8

Tepoxalin

Purity: ≥98%

Molecular weight: 385.84g/mol

Ref: 54-BUP02980

Tepoxalin

CAS: 103475-41-8

Tepoxalin (RWJ 20485), potential asthma and osteoarthritis drug, inhibits COX-1, COX-2, and 5-LOX with low IC50 values.

Formula: C₂₀H₂₀ClN₃O₃

Purity: 99.94%

Color and Shape: Solid

Molecular weight: 385.84

Ref: TM-T7724

Tepoxalin

Controlled Product

CAS: 103475-41-8

Applications Non-steroidal anti-inflammatory drug (NSAID) with potent anti-inflammatory and analgesic properties approved for veterinary use. It has inhibitory effect on cyclooxygenase and 5-lipxygenase activity as well as inhibiting the production of cytokines in peripheral cells outside the CNS.
References Argentieri, D.C. et al.: J. Pharmacol. Exp. Therap., 271, 1399 (1994); Agnello, K.A. et al.: Am. J. Vet. Res., 66, 966 (2005); Fiebich, B.L. et al.: Neuropharmacol., 38, 1325 (1999);

Formula: C₂₀H₂₀ClN₃O₃

Color and Shape: White Crystalline

Molecular weight: 385.84

Ref: TR-T103250