CAS 1035-77-4

Estradiol 3-methyl ether

Description:

Estradiol 3-methyl ether, with the CAS number 1035-77-4, is a synthetic derivative of estradiol, a principal estrogen hormone in humans. This compound is characterized by the presence of a methyl ether group at the 3-position of the estradiol structure, which alters its biological activity and solubility. Estradiol 3-methyl ether exhibits estrogenic properties, making it relevant in various pharmacological applications, particularly in hormone replacement therapy and the treatment of estrogen-related conditions. The compound is typically a white to off-white crystalline solid, and it is soluble in organic solvents such as ethanol and chloroform, but less soluble in water. Its molecular structure includes a steroid backbone, which is common among steroid hormones, contributing to its interaction with estrogen receptors. As with many synthetic estrogens, it is important to consider its pharmacokinetics, potential side effects, and the implications of long-term use in therapeutic contexts. Safety and handling precautions are essential due to its hormonal activity.

Formula: C₁₉H₂₆O₂

InChI: InChI=1S/C19H26O2/c1-19-10-9-15-14-6-4-13(21-2)11-12(14)3-5-16(15)17(19)7-8-18(19)20/h4,6,11,15-18,20H,3,5,7-10H2,1-2H3/t15-,16-,17+,18+,19+/m1/s1

InChI key: InChIKey=ULAADVBNYHGIBP-GFEQUFNTSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OC)=CC4)(CC1)[H])[H])(CC[C@@H]2O)[H]

Synonyms:

• (17-beta)-3-Methoxyestra-1,3,5(10)-trien-17-ol
• (17β)-3-Methoxyestra-1,3,5(10)-trien-17-ol
• (8Xi,9Xi,14Xi,17Beta)-3-Methoxyestra-1,3,5(10)-Trien-17-Ol
• 17-beta-Estradiol 3-methyl ether
• 17beta-Estradiol 3-methyl ether
• 17β-Estradiol 3-methyl ether
• 17β-Hydroxy-3-methoxyestra-1,3,5(10)-triene
• 3-Methoxy-13β-methyl-1,3,5(10)-gonatrien-17β-ol
• 3-Methoxy-17β-hydroxyestra-1,3,5(10)-triene
• 3-Methoxy-estra-1,3,5(10)-triene-17-beta-ol
• 3-Methoxyestra-1,3,5(10)-trien-17-beta-ol
• 3-Methoxyestra-1,3,5(10)-trien-17β-ol
• 3-Methoxyestra-1,3,5(10)-triene-17β-ol
• 3-Methoxyestra-1,3,5(10)-triene-3,17β-diol
• 3-Methoxyestradiol
• 3-Methoxyoestra-1,3,5(10)-trien-17-beta-ol
• 3-Methoxyoestra-1,3,5(10)-trien-17β-ol
• 3-Methoxyoestradiol
• 3-O-Methylestradiol
• Estra-1,3,5(10)-trien-17-beta-ol, 3-methoxy-
• Estra-1,3,5(10)-trien-17-ol, 3-methoxy-, (17-beta)- (9CI)
• Estra-1,3,5(10)-trien-17-ol, 3-methoxy-, (17β)-
• Estra-1,3,5(10)-trien-17beta-ol, 3-methoxy- (8CI)
• Estra-1,3,5(10)-trien-17β-ol, 3-methoxy-
• Estradiol 3-methyl ether
• Estradiol-17beta-3-methyl ether
• Nsc 58851

(8R,9S,13S,14S,17S)-3-Methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

CAS: 1035-77-4

Formula: C₁₉H₂₆O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 286.4085

Ref: IN-DA003DVQ

Estradiol 3-Methyl Ether

CAS: 1035-77-4

Formula: C₁₉H₂₆O₂

Color and Shape: White To Off-White Solid

Molecular weight: 286.42

Ref: 4Z-E-0972

Estradiol 3-Methyl Ether

Controlled Product

CAS: 1035-77-4

Formula: C₁₉H₂₆O₂

Color and Shape: Neat

Molecular weight: 286.41

Ref: 86-MM0123.15

3-O-Methyl Estradiol

Controlled Product

CAS: 1035-77-4

Applications Estradiol derivative which shows antioxidant activity.
References Fotsis, T., et al.: J. Steroid. Biochem., 28, 215 (1987), Sack, M., et al.: Lancet, 343, 269 (1994), Brunelli, R., et al.: Biochemistry, 39, 13897 (2000), Li, A., et al.: Nat. Med., 8, 1235 (2002),

Formula: C₁₉H₂₆O₂

Color and Shape: White To Light Yellow

Molecular weight: 286.41

Ref: TR-M304700

beta-Estradiol 3-methyl ether

Controlled Product

CAS: 1035-77-4

Beta-estradiol 3-methyl ether is a synthetic estrogen that is used as an oral contraceptive. It has been shown to be effective in the treatment of secondary amenorrhea and menorrhagia, as well as in the prevention of pregnancy. Beta-estradiol 3-methyl ether has been shown to increase fibrinogen levels and may be useful in the treatment of thrombocytopenia. A bolus dose of beta-estradiol 3-methyl ether may also be used to induce abortion, resulting in a decrease in blood pressure. The active form is taken up by cells via passive diffusion and is converted into estradiol by cytochrome P450 enzymes. Beta-estradiol 3-methyl ether binds to fatty acids with two or more carbon atoms, which then enter the cell by facilitated diffusion through specific membrane protein carriers. These carriers are blocked by atropine sulfate, preventing uptake of beta-estradiol 3-methyl ether

Formula: C₁₉H₂₆O₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 286.41 g/mol

Ref: 3D-FE66120

3-O-Methyl Estradiol-d5

Controlled Product

CAS: 1035-77-4

Formula: C₁₉D₅H₂₁O₂

Color and Shape: Neat

Molecular weight: 291.439

Ref: TR-M304703

3-O-Methyl Estradiol

CAS: 1035-77-4

Formula: C₁₉H₂₆O₂

Molecular weight: 286.4

Ref: ST-EA-CP-E58008