CAS 1035270-39-3

AZD-4547

Description:

AZD-4547 is a small molecule inhibitor primarily targeting the fibroblast growth factor receptor (FGFR) family, particularly FGFR1, FGFR2, and FGFR3. It is classified as a selective tyrosine kinase inhibitor and has been investigated for its potential therapeutic applications in various cancers, especially those characterized by FGFR aberrations. The compound exhibits a specific mechanism of action by blocking the phosphorylation of FGFR, thereby inhibiting downstream signaling pathways that promote tumor growth and survival. AZD-4547 is typically administered orally and has been evaluated in clinical trials for its efficacy and safety profile in treating conditions such as bladder cancer and other solid tumors. Its chemical structure includes a core that allows for high affinity and selectivity towards FGFRs, making it a subject of interest in targeted cancer therapies. As with many investigational drugs, ongoing research continues to explore its full potential, including resistance mechanisms and combination therapies to enhance its effectiveness.

Synonyms:

• Azd4547

rel-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide

CAS: 1035270-39-3

Formula: C₂₆H₃₃N₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 463.5719

Ref: IN-DA008TDR

AZD4547

CAS: 1035270-39-3

AZD4547

Purity: ≥98%

Molecular weight: 463.57g/mol

Ref: 54-BUP15331

AZD4547

CAS: 1035270-39-3

AZD4547 is an FGFR family inhibitor, and is able to act on FGFR1, FGFR2, FGFR3 and FGFR4. IC50:165 nM).Cost-effective and quality-assured.

Formula: C₂₆H₃₃N₅O₃

Purity: 99.37% - 99.88%

Color and Shape: Solid

Molecular weight: 463.57

Ref: TM-T1948

AZD 4547

CAS: 1035270-39-3

Inhibitor of fibroblast growth factor receptors (FGFR1, FGFR2 and FGFR3). Demonstrated anti-tumor effects in pre-clinical models of FGFR-driven tumors. AZD 4547 resulted in tumor progression when applied on a patient-derived model of FGFR1-amplified squamous cell lung disease. Antineoplastic effects also observed in FGFR2-amplified gastric cancer.

Formula: C₂₆H₃₃N₅O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 463.57 g/mol

Ref: 3D-FA64951

AZD4547

Controlled Product

CAS: 1035270-39-3

Applications AZD4547 is a bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinases. AZD4547 is particularly effective in inhibiting FGFR1, 2, and 3 tyrosine kinases and is under clinical investigation for the treatment of FGFR-dependent tumors.
References Gavine, P.R. et al.: Cancer Res., 72, 2045 (2012);

Formula: C₂₆H₃₃N₅O₃

Color and Shape: Neat

Molecular weight: 463.57

Ref: TR-A808120