CAS 1036915-08-8

2′-C-Methylguanosine 5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate]

Description:

2′-C-Methylguanosine 5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate] is a complex chemical compound characterized by its unique structural features that include a modified guanosine base, a phosphoramidate linkage, and a thioether moiety. The presence of the 2′-C-methyl group enhances its stability and may influence its biological activity, particularly in nucleic acid interactions. The phosphoramidate group is known for its ability to form stable linkages with nucleotides, making it relevant in the context of oligonucleotide synthesis and potential therapeutic applications. Additionally, the thioether component contributes to the compound's overall hydrophobicity and may affect its solubility and permeability in biological systems. This compound is of interest in medicinal chemistry and molecular biology, particularly for its potential roles in gene regulation and as a tool in RNA research. Its CAS number, 1036915-08-8, serves as a unique identifier for regulatory and research purposes.

Formula: C₂₅H₃₅N₆O₉PS

InChI: InChI=1S/C25H35N6O9PS/c1-24(2,13-32)22(35)42-10-9-38-41(37,28-11-15-7-5-4-6-8-15)39-12-16-18(33)25(3,36)21(40-16)31-14-27-17-19(31)29-23(26)30-20(17)34/h4-8,14,16,18,21,32-33,36H,9-13H2,1-3H3,(H,28,37)(H3,26,29,30,34)/t16-,18-,21-,25-,41?/m1/s1

InChI key: InChIKey=FGHMGRXAHIXTBM-TWFJNEQDSA-N

SMILES: C[C@]1(O)[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(NCC4=CC=CC=C4)(OCCSC(C(CO)(C)C)=O)=O)[C@H]1O

Synonyms:

• 2′-C-Methylguanosine 5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate]
• Guanosine, 2′-C-methyl-, 5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate]
• IDX 184

IDX184

CAS: 1036915-08-8

IDX184

Purity: ≥98%

Molecular weight: 626.62g/mol

Ref: 54-BUP01004

IDX184

CAS: 1036915-08-8

IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3

Formula: C₂₅H₃₅N₆O₉PS

Purity: 97.15%

Color and Shape: Solid

Molecular weight: 626.62

Ref: TM-T27586