CAS 103745-39-7

Fasudil

Description:

Fasudil is a pharmacological agent primarily recognized for its role as a selective inhibitor of Rho-kinase, an enzyme involved in various cellular processes, including smooth muscle contraction and cell migration. Its chemical formula is C14H18N4O2, and it is classified as a small molecule. Fasudil is often utilized in the treatment of conditions such as cerebral vasospasm following subarachnoid hemorrhage and has shown potential in various other therapeutic areas, including cardiovascular diseases and neuroprotection. The substance is typically administered in the form of a hydrochloride salt, enhancing its solubility and bioavailability. Fasudil exhibits properties such as anti-inflammatory effects and the ability to improve blood flow by relaxing vascular smooth muscle. Its mechanism of action involves the modulation of the RhoA/Rho-kinase signaling pathway, which plays a crucial role in regulating vascular tone and remodeling. As with any pharmacological agent, the use of Fasudil may be accompanied by side effects, and its safety profile is an important consideration in clinical applications.

Formula: C₁₄H₁₇N₃O₂S

InChI: InChI=1/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H

InChI key: InChIKey=NGOGFTYYXHNFQH-UHFFFAOYSA-N

SMILES: S(=O)(=O)(C=1C2=C(C=CC1)C=NC=C2)N3CCCNCC3

Synonyms:

• (5-Isoquinolinesulfonyl)Homopiperazine
• 1-(5-Isoquinolinesulfonyl)homopiperazine
• 1-(5-Isoquinolinesulphonyl)homopiperazine
• 1-(5-Isoquinolinylsulfonyl)homopiperazine
• 103745-39-7
• 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-
• 5-(1,4-Diazepan-1-Ylsulfonyl)Isoquinoline Dihydrochloride
• 5-(1,4-Diazepan-1-Ylsulfonyl)Isoquinoline Hydrochloride (1:1)
• 5-(1,4-Diazepan-1-ylsulfonyl)isoquinoline
• 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]isoquinoline
• At 877
• Ha 1077
• Hexahydro-1-(5-isoquinolinesulfonyl)-1H-1,4-diazepine
• N-(5-Isoquinolinesulfonyl)-1,4-perhydrodiazepine
• isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-
• at877
• HA-1077 DIHYDROCHLORIDE NOVEL VASODILATO R AGE
• 2,3,4,5,6,7-Hexahydro-1-(isoquinolin-5-ylsulfonyl)-1H-1,4-diazepine
• HA 1077, DIHYDROCHLORIDE, 99+%
• 5-(Hexahydro-1H-1,4-diazepine-1-ylsulfonyl)isoquinoline
• FASUDIL
• Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine
• HA-1077：Eril
• 1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE

Fasudil Hydrochloride

CAS: 103745-39-7, 105628-07-7, 186694-02-0

Formula: C₁₄H₁₇N₃O₂S·HCl

Purity: >96.0%(HPLC)(qNMR)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 327.83

Ref: 3B-F0839

Fasudil, 98+%

CAS: 103745-39-7

HA-1077 dihydrochloride has been shown to be a vasodilating agent as well as a potent inhibitor of Rock-2 (Rho-associated Kinase II), cGKI (cGMP-dependent protein kinase), PKA (cAMP-dependent protein kinase), MYLK, and CaMKII. Rho kinase signaling pathways are thought to cause invasion, migration, a

Formula: C₁₄H₁₇N₃O₂S

Purity: 98+%

Molecular weight: 327.83

Ref: 02-J63525

5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]isoquinoline

CAS: 103745-39-7

Formula: C₁₄H₁₇N₃O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 291.3687

Ref: IN-DA00HA6E

Fasudil

CAS: 103745-39-7

Formula: C₁₄H₁₇N₃O₂S

Purity: ≥ 98.0%

Color and Shape: White to off-white solid

Molecular weight: 327.83

Ref: 7W-GP2490

Fasudil

CAS: 103745-39-7

Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.

Formula: C₁₄H₁₇N₃O₂S

Purity: 99.79% - 99.84%

Color and Shape: Solid

Molecular weight: 291.37

Ref: TM-T1606

Fasudil

CAS: 103745-39-7

Fasudil

Purity: ≥98%

Molecular weight: 291.37g/mol

Ref: 54-BUP15962

Fasudil

CAS: 103745-39-7

Formula: C₁₄H₁₇N₃O₂S

Color and Shape: Neat

Ref: TR-F150023

Fasudil

CAS: 103745-39-7

Fasudil is a rho-kinase inhibitor that prevents the phosphorylation of myosin light chain and inhibits the polymerization of actin, thereby inhibiting cell contraction. Fasudil has been shown to be effective in treating primary pulmonary hypertension by preventing tubulointerstitial injury, as well as in reducing atherosclerotic lesions. It also reduces the expression of growth factor-β1, which may contribute to its therapeutic effects on certain cardiovascular diseases.
Fasudil is available as an injection solution at a concentration of 50mg/mL. It can also be formulated into tablets for oral administration at a dose of 25mg or 50mg per day.

Formula: C₁₄H₁₇N₃O₂S

Purity: Min. 95%

Molecular weight: 327.83 g/mol

Ref: 3D-DEA74539