CAS 103766-25-2
:GIMERACIL
Description:
Gimeracil, with the CAS number 103766-25-2, is a chemical compound primarily known for its role as a pharmacological agent. It is classified as a pyrimidine derivative and functions as a potent inhibitor of the enzyme dihydropyrimidine dehydrogenase (DPD), which is involved in the metabolism of pyrimidine analogs. This inhibition enhances the efficacy of certain chemotherapeutic agents, particularly fluoropyrimidines like 5-fluorouracil, by prolonging their action and reducing their degradation. Gimeracil is often used in combination therapies for cancer treatment, particularly in gastrointestinal malignancies. The compound is characterized by its ability to improve the therapeutic index of chemotherapy while potentially minimizing side effects associated with rapid drug metabolism. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are crucial for its effectiveness in clinical settings. As with any pharmaceutical agent, understanding its mechanism of action, potential interactions, and side effects is essential for optimizing its use in cancer therapy.
Formula:C5H4ClNO2
InChI:InChI=1/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9)
InChI key:InChIKey=ZPLQIPFOCGIIHV-UHFFFAOYSA-N
SMILES:OC=1C(Cl)=CNC(=O)C1
Synonyms:- 2(1H)-Pyridinone, 5-chloro-4-hydroxy-
- 5-Chloro-2,4-dihydroxypyridine
- 5-Chloro-4-hydroxy-2(1H)-pyridinone
- 5-Chloro-4-hydroxy-2-pyridone
- 5-Chloropyridine-2,4-Diol
- Cdhp
- Gimestat
- Gimeracil
- Gimeracil,(CDHP)
- 2(1H)-Pyridinone,5-chloro-4-hydroxy-(9CI)
- （CDHP）Gimeracil
- See more synonyms
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Found 11 products.
Gimeracil
CAS:Formula:C5H4ClNO2Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:145.545-Chloro-2,4-Dihydroxypyridine
CAS:Formula:C5H4ClNO2Purity:98%Color and Shape:SolidMolecular weight:145.5438Gimeracil
CAS:Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.Formula:C5H4ClNO2Purity:99.80%Color and Shape:SolidMolecular weight:145.545-Chloro-2,4-dihydroxypyridine
CAS:5-Chloro-2,4-dihydroxypyridinePurity:98%Molecular weight:145.54g/molGimeracil
CAS:Controlled ProductApplications Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).
References Shirasaka, T., et al.: Cancer Res., 56, 2602 (1996), Patt, Y., et al.: J. Clin. Oncol., 22, 271 (2004), Shirao, K., et al.: Cancer, 100, 2355 (2004), Kelly, H., et al.: J. Clin. Oncol., 23, 4553 (2005),Formula:C5H4ClNO2Color and Shape:NeatMolecular weight:145.54Gimeracil - Bio-X ™
CAS:This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C5H4NO2ClPurity:Min. 95%Color and Shape:PowderMolecular weight:145.54 g/molGimeracil
CAS:Gimeracin is a prodrug that is hydrolyzed in vivo to gimeracil and acetic acid. Gimeracin has been shown to inhibit glucose uptake into cells, which may be due to its inhibition of the sodium-glucose co-transporter 1 (SGLT1). Gimeracin has also been shown to produce cytotoxic effects on human cancer cells, with the potential for radiation therapy. The mechanism of toxicity may be related to the production of reactive oxygen species.Formula:C5H4NO2ClPurity:Min. 98 Area-%Color and Shape:Slightly Yellow PowderMolecular weight:145.54 g/mol
