CAS 103775-10-6

Moexipril

Description:

Moexipril is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. It functions by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure. The chemical formula of Moexipril is C20H26N2O5, and it features a unique structure that includes a proline derivative, which contributes to its pharmacological activity. Moexipril is typically administered in its hydrochloride salt form, enhancing its solubility and bioavailability. The substance is characterized by its moderate lipophilicity, allowing for effective absorption and distribution in the body. Common side effects may include dizziness, cough, and elevated potassium levels, among others. As with other ACE inhibitors, it is contraindicated in pregnancy due to potential teratogenic effects. Overall, Moexipril represents a valuable therapeutic option in managing cardiovascular conditions, with its efficacy supported by clinical studies.

Formula: C₂₇H₃₄N₂O₇

InChI: InChI=1S/C27H34N2O7/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32)/t17-,21-,22-/m0/s1

InChI key: InChIKey=UWWDHYUMIORJTA-HSQYWUDLSA-N

SMILES: C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(OCC)=O)C)(=O)N2CC=3C(C[C@H]2C(O)=O)=CC(OC)=C(OC)C3

Synonyms:

• (3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid
• 3-Isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, (3S)-
• 2-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1h-isoquinoline-3-carboxylic acid
• RS 10085
• (3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• Moexipril
• 3-Isoquinolinecarboxylic acid, 2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, [3S-[2[R*(R*)],3R*]]-
• 2-{N-[1-(ethoxycarbonyl)-3-phenylpropyl]alanyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• MoexiprilC27H34N207

Moexipril

CAS: 103775-10-6

Moexipril is an oral ACE inhibitor, lipid-soluble, targets plasma/tissue ACE, and is used for cardiovascular research.

Formula: C₂₇H₃₄N₂O₇

Color and Shape: Solid

Molecular weight: 498.57

Ref: TM-T63377