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CAS 103848-61-9

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N-(epsilon-Maleimidocaproyloxy)sulfosuccinimide

Description:
N-(epsilon-Maleimidocaproyloxy)sulfosuccinimide, commonly referred to as sulfo-SMCC, is a water-soluble crosslinker used in bioconjugation and protein chemistry. It features a maleimide group that allows for selective conjugation to thiol groups on proteins, facilitating the formation of stable thioether bonds. The sulfonate group enhances its solubility in aqueous solutions, making it particularly useful for biological applications. This compound typically exhibits a moderate molecular weight and is characterized by its ability to react under mild conditions, preserving the integrity of sensitive biomolecules. Its reactivity is pH-dependent, with optimal conditions often around neutral pH. Sulfo-SMCC is widely utilized in the development of antibody-drug conjugates, protein labeling, and the creation of complex biomolecular structures. Safety considerations include handling it in a well-ventilated area and using appropriate personal protective equipment, as it may cause irritation upon contact. Overall, sulfo-SMCC is a valuable tool in the field of biochemistry and molecular biology for creating targeted and effective conjugates.
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