CAS 103890-78-4: Lacidipine
Description:Lacidipine is a calcium channel blocker primarily used as an antihypertensive agent. It belongs to the dihydropyridine class of compounds and is characterized by its ability to selectively inhibit L-type calcium channels, leading to vasodilation and a subsequent decrease in blood pressure. The molecular structure of Lacidipine includes a dihydropyridine ring, which is essential for its pharmacological activity. It is known for its long half-life, allowing for once-daily dosing, which enhances patient compliance. Lacidipine exhibits lipophilic properties, facilitating its absorption and distribution in the body. Additionally, it has been noted for its potential antioxidant effects, which may contribute to its cardiovascular benefits beyond blood pressure reduction. The substance is typically administered in tablet form and may have side effects such as peripheral edema or flushing, although it is generally well-tolerated. Overall, Lacidipine represents an important therapeutic option in the management of hypertension, particularly in patients who may benefit from its unique pharmacokinetic profile.
Formula:C26H33NO6
InChI:InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+
InChI key:InChIKey=GKQPCPXONLDCMU-CCEZHUSRSA-N
SMILES:O=C(OC(C)(C)C)C=CC=1C=CC=CC1C2C(C(=O)OCC)=C(NC(=C2C(=O)OCC)C)C
- Synonyms:
- (E)-4-[2-[3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester
- 3,5-Pyridinedicarboxylic acid, 4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
- 3,5-Pyridinedicarboxylic acid, 4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-, diethyl ester
- 3,5-Pyridinedicarboxylic acid, 4-[2-[3-(1,1-dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-, diethyl ester, (E)-
- 3,5-pyridinedicarboxylic acid, 4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-, diethyl ester
- 4-[o-[(E)-2-Carboxyvinyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid 4-tert-Butyl Diethyl Ester
- Caldine
- Diethyl (E)-4-[2-[2-(tert-butoxycarbonyl)vinyl]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- Diethyl 4-{2-[(1E)-3-tert-butoxy-3-oxoprop-1-en-1-yl]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- Gr 43659X
- See more synonyms
- Gx 1048
- Lacimen
- Lacipil
- Lacirex
- Midotens
- Motens