CAS 1038915-64-8: Niraparib Hydrochloride

Description:Niraparib Hydrochloride is a small molecule inhibitor primarily used in cancer therapy, particularly for the treatment of ovarian cancer. It functions as a potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair processes. By inhibiting PARP, Niraparib disrupts the repair of single-strand breaks in DNA, leading to the accumulation of DNA damage and ultimately inducing apoptosis in cancer cells, especially those with BRCA mutations. The hydrochloride salt form enhances its solubility and stability, facilitating its administration. Niraparib is typically administered orally and has been associated with various side effects, including fatigue, nausea, and hematological toxicities. Its pharmacokinetics indicate a relatively long half-life, allowing for once-daily dosing. The substance is classified as a targeted therapy, representing a significant advancement in personalized medicine for patients with specific genetic profiles in their tumors. As with any medication, its use should be guided by a healthcare professional, considering the individual patient's condition and treatment history.

Found 3 products.

Product data	Purity	Price range	Estimated delivery
MK-4827 (HCl) REF: IN-DA008TI3CAS: 1038915-64-8	98%	94.00 €~312.00 €	Tue 04 Mar 25
Niraparib hydrochloride REF: TM-T3353CAS: 1038915-64-8	99.26%	40.00 €~216.00 €	Tue 11 Mar 25
Niraparib hydrochloride REF: 3D-NRB91564CAS: 1038915-64-8	Min. 95%	To inquire	Tue 15 Apr 25