CAS 103962-10-3

4-(trifluoromethoxy)phenacyl bromide

Description:

4-(Trifluoromethoxy)phenacyl bromide is an organic compound characterized by its phenacyl structure, which features a phenyl group attached to a carbonyl group and a bromide substituent. The presence of the trifluoromethoxy group enhances its reactivity and polarity, making it a useful intermediate in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. This compound typically exhibits a crystalline solid form and is soluble in organic solvents. Its trifluoromethoxy group contributes to its unique electronic properties, influencing its behavior in chemical reactions, such as nucleophilic substitutions. Additionally, the bromide moiety can participate in various coupling reactions, making it a versatile building block in synthetic chemistry. Safety precautions should be observed when handling this compound, as it may pose health risks due to its halogenated nature. Overall, 4-(trifluoromethoxy)phenacyl bromide is notable for its functional groups that facilitate diverse chemical transformations.

Formula: C₉H₆BrF₃O₂

InChI: InChI=1S/C9H6BrF3O2/c10-5-8(14)6-1-3-7(4-2-6)15-9(11,12)13/h1-4H,5H2

SMILES: c1cc(ccc1C(=O)CBr)OC(F)(F)F

Synonyms:

• 2-Bromo-4-Trifluoromethoxyacetophenone
• 2-Bromo-4'-(trifluoromethoxy)acetophenone

2-Bromo-4'-(trifluoromethoxy)acetophenone, 97%

CAS: 103962-10-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₉H₆BrF₃O₂

Purity: 97%

Molecular weight: 283.04

Ref: 02-H64105

Ethanone, 2-​bromo-​1-​[4-​(trifluoromethoxy)​phenyl]​-

CAS: 103962-10-3

Formula: C₉H₆BrF₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 283.0419

Ref: IN-DA003KB7

4-(Trifluoromethoxy)phenacyl bromide

CAS: 103962-10-3

4-(Trifluoromethoxy)phenacyl bromide

Formula: C₉H₆BrF₃O₂

Purity: 97%

Color and Shape: colourless to faint yellow crystals

Molecular weight: 283.04g/mol

Ref: 54-PC7439KM

4-(Trifluoromethoxy)phenacyl bromide

CAS: 103962-10-3

Formula: C₉H₆BrF₃O₂

Purity: 97%

Color and Shape: Solid, White crystalline powder

Molecular weight: 283.044

Ref: 10-F007562

2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one

Controlled Product

CAS: 103962-10-3

Applications 2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one is an intermediate used to prepare aminothiazoles as therapeutic leads for prion diseases. It is also used in the synthesis of pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.
References Gallardo-Godoy, A., et al.: J. Med. Chem., 54, 1010 (2011); Keith, J., et al.: Bioorg. Med. Chem. Lett., 17, 2603 (2007)

Formula: C₉H₆BrF₃O₂

Color and Shape: Neat

Molecular weight: 283.04

Ref: TR-B200055