CAS 103980-44-5

Ceftiofur hydrochloride

Description:

Ceftiofur hydrochloride is a broad-spectrum cephalosporin antibiotic primarily used in veterinary medicine for the treatment of bacterial infections in livestock and poultry. It is effective against a variety of Gram-positive and Gram-negative bacteria, making it a valuable tool in managing infections such as respiratory diseases and mastitis. The compound is characterized by its stability in the presence of beta-lactamases, enzymes produced by some bacteria that confer resistance to other antibiotics. Ceftiofur hydrochloride is typically administered via injection, and its pharmacokinetics allow for effective tissue penetration, which is crucial for treating systemic infections. The substance is generally well-tolerated, but like all antibiotics, it may lead to adverse effects, including allergic reactions or disruption of normal flora. Due to its use in food-producing animals, there are regulations regarding withdrawal times before slaughter to ensure that antibiotic residues do not enter the food supply. Overall, Ceftiofur hydrochloride plays a significant role in veterinary medicine, contributing to animal health and productivity.

Formula: C₁₉H₁₇N₅O₇S₃·ClH

InChI: InChI=1S/C19H17N5O7S3.ClH/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10;/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28);1H/b23-11-;/t12-,16-;/m1./s1

InChI key: InChIKey=KEQFDTJEEQKVLM-JUODUXDSSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C3=CSC(N)=N3)=O)C2=O)(SCC1CSC(=O)C4=CC=CO4)[H].Cl

Synonyms:

• (6R,7R)-7-[2-(2-Aminothiazol-4-yl)-2-(methylimino)actylamino] -3-[(2-furanylcarbonyl) thiomethyl]-3-cephem-4-carboxylic acid Hydrochloride
• (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(furan-2-ylcarbonyl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
• (6R-(6Alpha,7Beta(Z))-7-(((2-Amino-4-Thiazolyl)(Methoxyimino)Acetyl)Amino)-3-(((2-Furanylcarbonyl)Thio)Methyl)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Hydrochloride
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-, monohydrochloride, [6R-[6α,7β(Z)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-, monohydrochloride, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-, hydrochloride (1:1), (6R,7R)-
• 7-[(Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxy-imino)acetamido]-3-(2-furoylthiomethyl)-3-cephem-4-carboxylic acid Hydrochloride
• 7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(furan-2-ylcarbonyl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride (1:1)
• Aviar
• Cefalus
• Ceftiofur hcl
• Excenel
• Excenel RTU
• Spectramast LC
• U 64279A
• U 67279A

Ceftiofur Hydrochloride

CAS: 103980-44-5

Antibiotics nesoi

Formula: C₁₉H₁₇N₅O₇S₃·HCl

Color and Shape: White Beige Powder

Molecular weight: 559.00569

Ref: 45-1098071

Ceftiofur, HCl

CAS: 103980-44-5

Formula: C₁₉H₁₈ClN₅O₇S₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 560.0235

Ref: IN-DA00HA8L

Ceftiofur hydrochloride

CAS: 103980-44-5

Formula: C₁₉H₁₇N₅O₇S₃·HCl

Purity: ≥ 97.5%

Color and Shape: White, off-white or pale yellow powder

Molecular weight: 560.02

Ref: 7W-GA9252

Ceftiofur HCl

CAS: 103980-44-5

Formula: C₁₉H₁₇N₅O₇S₃·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 523.55 36.46

Ref: 4Z-C-861

Ceftiofur hydrochloride

CAS: 103980-44-5

Ceftiofur hydrochloride (U-67279A) is a stable, broad-spectrum 3rd-gen cephalosporin with antibacterial properties.

Formula: C₁₉H₁₇N₅O₇S₃·HCl

Purity: 99.51%

Color and Shape: Off-White Solid

Molecular weight: 560.02

Ref: TM-T6268

Ceftiofur hydrochloride

CAS: 103980-44-5

Ceftiofur hydrochloride

Purity: ≥98%

Molecular weight: 560.02g/mol

Ref: 54-BUP18283

Ceftiofur hydrochloride

Controlled Product

CAS: 103980-44-5

Formula: C₁₉H₁₇N₅O₇S₃·ClH

Color and Shape: Neat

Molecular weight: 560.02

Ref: 04-C11065020

Ceftiofur Hydrochloride

CAS: 103980-44-5

Applications An antibacterial.
References Yancey, R.J., et al.: Am. J. Vet. Res., 48, 1050 (1987)

Formula: C₁₉H₁₇N₅O₇S₃·ClH

Color and Shape: Colourless To Off-White

Molecular weight: 560.02

Ref: TR-C244700

Ceftiofur hydrochloride

CAS: 103980-44-5

Ceftiofur hydrochloride is an antimicrobial agent that belongs to the group of cephalosporins. It has inhibitory activity against gram-positive bacteria and is used for the treatment of infectious diseases, such as bovine respiratory disease (BRD) and swine dysentery. Ceftiofur hydrochloride is a prodrug that can be hydrolyzed by esterases to ceftiofur sodium in vivo, which has a longer half-life and a broader spectrum of activity than ceftiofur hydrochloride. Ceftiofur hydrochloride inhibits the growth of microorganisms by binding to one or more penicillin-binding proteins, which leads to cell lysis. Ceftiofur hydrochloride also has drug interactions with tetracycline and amoxicillin/clavulanic acid due to its inhibition of beta-lactamase enzymes.

Formula: C₁₉H₁₈ClN₅O₇S₃

Purity: Min. 96 Area-%

Color and Shape: White Powder

Molecular weight: 560.03 g/mol

Ref: 3D-FC19878