CAS 104004-96-8

Metapristone

Description:

Metapristone, with the CAS number 104004-96-8, is a synthetic compound that belongs to the class of antiprogestins. It is primarily characterized by its ability to inhibit the action of progesterone, a hormone crucial for the regulation of various reproductive processes. Metapristone is often studied for its potential applications in reproductive health, particularly in the context of contraception and the management of certain gynecological conditions. The compound exhibits a high affinity for progesterone receptors, leading to the modulation of gene expression associated with progesterone signaling. Its pharmacological profile suggests that it may have effects on endometrial tissue, making it relevant in the treatment of conditions like endometriosis or uterine fibroids. Additionally, Metapristone's safety and efficacy are subjects of ongoing research, particularly in comparison to other antiprogestins. As with many synthetic hormones, understanding its pharmacokinetics, potential side effects, and interactions with other medications is crucial for its therapeutic application.

Formula: C₂₈H₃₃NO₂

InChI: InChI=1S/C28H33NO2/c1-4-14-28(31)15-13-25-23-11-7-19-16-21(30)10-12-22(19)26(23)24(17-27(25,28)2)18-5-8-20(29-3)9-6-18/h5-6,8-9,16,23-25,29,31H,7,10-13,15,17H2,1-3H3/t23-,24+,25-,27-,28-/m0/s1

InChI key: InChIKey=IBLXOBHABOVXDY-WKWWZUSTSA-N

SMILES: C[C@@]12[C@]([C@]3(C([C@H](C1)C4=CC=C(NC)C=C4)=C5C(CC3)=CC(=O)CC5)[H])(CC[C@]2(C#CC)O)[H]

Synonyms:

• (11,17)-17-Hydroxy-11-[4-(methylamino)phenyl]-17-(1-propyn-1-yl)-estra-4,9-dien-3-one
• (11Beta)-17-Hydroxy-11-[4-(Methylamino)Phenyl]-17-(Prop-1-Yn-1-Yl)Estra-4,9-Dien-3-One
• (11β,17β)-17-Hydroxy-11-[4-(methylamino)phenyl]-17-(1-propyn-1-yl)estra-4,9-dien-3-one
• Desmethylmifepristone
• Estra-4,9-dien-3-one, 17-hydroxy-11-[4-(methylamino)phenyl]-17-(1-propyn-1-yl)-, (11β,17β)-
• Estra-4,9-dien-3-one, 17-hydroxy-11-[4-(methylamino)phenyl]-17-(1-propynyl)-, (11β,17β)-
• Metapristone
• N-Demethyl Mifepristone
• N-Demethylmifepristone
• N-Desmethyl-RU 486
• N-Methylaminopristone

N-Demethyl Mifepristone-d3

CAS: 104004-96-8

Formula: C₂₈H₃₀D₃NO₂

Color and Shape: Yellow Solid

Molecular weight: 418.60

Ref: 4Z-M-2911

N-Desmethyl Mifepristone

CAS: 104004-96-8

Formula: C₂₈H₃₃NO₂

Color and Shape: Yellow Solid

Molecular weight: 415.58

Ref: 4Z-M-293

N-Demethyl Mifepristone

CAS: 104004-96-8

Applications A metabolite of Mifepristone (M343975).
References Ringler, I., et al.: Metabolism, 13, 37 (1964), Gagne, D., et al.: J. Steroid. Biochem., 25, 315 (1986), Jang, G., et al.: Biochem. Pharmacol., 52, 753 (1996), Hild, S., et al.: Hum. Reprod., 15, 822 (2000), Gainer, E., et al.: Steroids, 68, 1005 (2003),

Formula: C₂₈H₃₃NO₂

Color and Shape: Neat

Molecular weight: 415.57

Ref: TR-D230950

N-Demethyl mifepristone

Controlled Product

CAS: 104004-96-8

N-Demethyl mifepristone is a synthetic steroidal antiprogestin that is structurally similar to the natural progesterone. It is a prodrug of the anti-progestin, mifepristone, which is responsible for the antiprogestational effects of the drug. N-Demethyl mifepristone has been shown to have significant cytotoxicity in skin cancer cells and to inhibit epidermal growth factor-induced cell proliferation in cervical cancer cells. This drug also has pharmacokinetic properties that are different from those of mifepristone and may be less toxic than its parent compound.

Formula: C₂₈H₃₃NO₂

Purity: Min. 95%

Molecular weight: 415.57 g/mol

Ref: 3D-FD21006

N-Demethyl Mifepristone-d3

Controlled Product

CAS: 104004-96-8

Formula: C₂₈D₃H₃₀NO₂

Color and Shape: Neat

Molecular weight: 418.586

Ref: TR-D230952

N-Desmethyl Mifepristone

CAS: 104004-96-8

Formula: C₂₈H₃₃NO₂

Molecular weight: 415.5

Ref: ST-EA-CP-M61007

N-Demethyl Mifepristone

CAS: 104004-96-8

N-Demethyl Mifepristone (RU 42633), an active metabolite of Mifepristone, exhibits 61% of the affinity for the glucocorticoid receptor relative to Mifepristone'

Formula: C₂₈H₃₃NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 415.57

Ref: TM-T80652